Recombinant Mouse PML-RARA-regulated adapter molecule 1 (Pram1)

中文名稱：

小鼠Pram1重組蛋白
貨號：

CSB-YP715310MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Pram1重組蛋白
貨號：

CSB-EP715310MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Pram1重組蛋白
貨號：

CSB-EP715310MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Pram1重組蛋白
貨號：

CSB-BP715310MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Pram1重組蛋白
貨號：

CSB-MP715310MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Pram1
Uniprot No.：

Q6BCL1
別名：

Pram1; PML-RARA-regulated adapter molecule 1; PRAM-1
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-675
氨基酸序列

MGSNQDFRNL QAKFQTSQPE LGELFRKTPK PELNKVLKKF PQTELSEQPK KSSQSELSAV SLKPLQLQFA DLPRKPPQPG VLKKSPQPEF PHLANKPVQA EFPRKPLHPE FTGLKKPSQA EFTDLKKPPQ PQFASLPKKP PKPEFGELSK RPPQLETPQE PSAPPAQKLL KPEPNNPARP LGELKPKMFW HLEANEAPKR PLPSESSTFP KKPLQPEAVV GFSRKSQPQS ESIEVSQTSP SKCGSRELDS HSPQPDISTF PKNNENFRKP SYPQATGCPK SPKQPMFYEF PQTPPRKPES CNPQSHSPLP DFNAFPKKHP QLQPSDLTRA SSEPEVCKVP KKTQKPDPNV LSQKPSQPEL GHLPRTSSDP EFNSLPRKFL QPQHGKFFQP EFPKGLPRKP KLPGSVSECS LPSASAGSSP QCPLSPGLIV PGIPRWRSED FQVQRPPRRR PLPSASSLGH PPAKPALPPG PINIQSFRRA AATAAAVLKT GSSTGTHFQA QQPQHIAQNP DEIYELYDAV EATDDSSISP RGRDEMLSTQ QATRWPQQEP ELRKKATQPQ QLPATDPKLL KQIRKAEKAE REFRKKFKFE GEIVIHTKMM IDPNAKTRRG GGKHLGIRRG EILEVIEFTS KDEMLCRDPK GKYGYVPRTA LLPLETEVYD DVSFGDPLDM QPFPR
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P.
基因功能參考文獻：
1. A yopH mutant survived better in the absence of neutrophils, indicating that neutrophil inactivation by YopH by targeting PRAM-1/SKAP-HOM and SLP-76/Vav/PLCgamma2 signaling hubs may be critical for Yersinia survival. PMID: 24034616
2. autophagy contributes to the anti-apoptotic function of the PML-RARalpha protein through inhibiting the Akt/mTOR pathway PMID: 21673516
3. Transgenic mice expressing PML-RAR alpha develop acute promyelocytic leukemia with long latency, low penetrance, and acquired cytogenetic abnormalities. PMID: 16675706
組織特異性：

Expressed in bone marrow and mature neutrophils. Weakly expressed in macrophages and mast cells.
數據庫鏈接：

KEGG: mmu:378460

STRING: 10090.ENSMUSP00000057065

UniGene: Mm.272606