Recombinant Mouse O-acetyl-ADP-ribose deacetylase MACROD1 (Macrod1)

中文名稱：

小鼠Macrod1重組蛋白
貨號：

CSB-YP856370MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Macrod1重組蛋白
貨號：

CSB-EP856370MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Macrod1重組蛋白
貨號：

CSB-EP856370MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Macrod1重組蛋白
貨號：

CSB-BP856370MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Macrod1重組蛋白
貨號：

CSB-MP856370MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Macrod1
Uniprot No.：

Q922B1
別名：

Macrod1; Lrp16ADP-ribose glycohydrolase MACROD1; MACRO domain-containing protein 1; O-acetyl-ADP-ribose deacetylase MACROD1; EC 3.1.1.106; Protein LRP16; [Protein ADP-ribosylaspartate] hydrolase MACROD1; EC 3.2.2.-; [Protein ADP-ribosylglutamate] hydrolase MACROD1; EC 3.2.2.-
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-323
氨基酸序列

MSLQSQVSGR LAQLRAAGQL LVSLRPWPGR SAGGPRPRGS ACGPLVALGE HGYCAWLSAG VGAWGAAGRG AWVRTWAPLA MAAKVDLSTS TDWKEAKSFL KGLSDKQREE HYFCKDFIKL KKIPTWKETA KGLAVKVEDP KYKKDKQLNE KISLYRGDIT KLEVDAIVNA ANSSLLGGGG VDGCIHRAAG SLLTDECRTL QNCETGKAKI TCGYRLPAKY VIHTVGPIAV GQPTASQAAE LRSCYLSSLD LLLEHRLRSV AFPCISTGVF GYPNEEAAEV VLASLREWLE QHKDKVDRLI ICVFLEKDEG IYRERLPHYF PVA
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity.
基因功能參考文獻：
1. These results suggest that LRP16 plays a key role in maintaining pancreatic beta-cell functions and may help us to understand the protective effects of estrogen on the functions of pancreatic beta-cells. PMID: 22528219
2. LRP16 acts as a negative regulator of insulin action and adipogenesis in 3T3-L1 adipocytes. PMID: 23389992
3. LRP16 played important roles not only in insulin content and GSIS but also in the antilipotoxic effect mediated by Akt/FoxO1 signaling. PMID: 22800886
4. LRP16 gene causes insulin resistance in C2-C12 cells by inhibiting the IRS-1 signaling and the transcriptional activity of PPARgamma. PMID: 21756814
亞細胞定位：

Nucleus.
數據庫鏈接：

KEGG: mmu:107227

STRING: 10090.ENSMUSP00000039507

UniGene: Mm.439977