Recombinant Mouse Notchless protein homolog 1 (Nle1)

中文名稱：

小鼠Nle1重組蛋白
貨號：

CSB-YP819766MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Nle1重組蛋白
貨號：

CSB-EP819766MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Nle1重組蛋白
貨號：

CSB-EP819766MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Nle1重組蛋白
貨號：

CSB-BP819766MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Nle1重組蛋白
貨號：

CSB-MP819766MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Nle1
Uniprot No.：

Q8VEJ4
別名：

Nle1; Notchless protein homolog 1
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

2-485
氨基酸序列

AAAVVEEAA AGDVQRLLVQ FQDEGGQLLG SPFDVPVDIT PDKLQLVCNA LLAQEEPLPL AFYVHDAEIV SSLGKTLESQ SVETEKIVDI IYQPQAVFRV RAVTRCTSSL EGHSEAVISV AFSPTGKYLA SGSGDTTVRF WDLSTETPHF TCKGHRHWVL SISWSPDGKK LASGCKNGQV LLWDPSTGLQ VGRTLTGHSK WITGLSWEPL HMNPECRYVA SSSKDGSVRV WDTTAGRCER ILTGHTQSVT CLRWGGDGLL YSASQDRTIK VWRAHDGVLC RTLQGHGHWV NTMALSTDYA LRTGAFEPAE ATVNAQDLQG SLKELKERAS SRYNLVRGQG PERLVSGSDD FTLFLWSPAE DKKPLARMTG HQALINQVLF SPDSRIVASA SFDKSIKLWD GRTGKYLASL RGHVAAVYQI AWSADSRLLV SGSSDSTLKV WDVKAQKLAT DLPGHADEVY AVDWSPDGQR VASGGKDKCL RIWRR
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival.
基因功能參考文獻：
1. These data demonstrate an essential role for Nle1 during organogenesis and in particular during axial development. PMID: 24875805
2. These indings establish an essential role for Nle in hematopoietic stem cells. PMID: 24062412
3. mNle is mainly required in inner cell mass cells, being instrumental for their survival, and raise the possibility that the death of mNle-deficient embryos might result from abnormal Notch signaling during the first steps of development. PMID: 16611995
亞細胞定位：

Nucleus, nucleolus.
組織特異性：

Highest expression in heart, brain, lung, liver, skeletal muscle and testis with lower levels in spleen and kidney.
數據庫鏈接：

KEGG: mmu:217011

STRING: 10090.ENSMUSP00000099502

UniGene: Mm.29176