Recombinant Mouse Nicotinamide mononucleotide adenylyltransferase 3 (Nmnat3)

中文名稱：

小鼠Nmnat3重組蛋白
貨號：

CSB-YP859539MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Nmnat3重組蛋白
貨號：

CSB-EP859539MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Nmnat3重組蛋白
貨號：

CSB-EP859539MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Nmnat3重組蛋白
貨號：

CSB-BP859539MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Nmnat3重組蛋白
貨號：

CSB-MP859539MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Nmnat3
Uniprot No.：

Q99JR6
別名：

Nmnat3; Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3; NMN/NaMN adenylyltransferase 3; EC 2.7.7.1; EC 2.7.7.18; Nicotinamide-nucleotide adenylyltransferase 3; NMN adenylyltransferase 3; Nicotinate-nucleotide adenylyltransferase 3; NaMN adenylyltransferase 3
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-245
氨基酸序列

MKNRIPVVLL ACGSFNPITN MHLRLFEVAR DHLHQTGRYQ VIEGIISPVN DSYGKKDLVA SHHRVAMARL ALQTSDWIRV DPWESEQAQW METVKVLRHH HRELLRSSAQ MDGPDPSKTP SASAALPELK LLCGADVLKT FQTPNLWKDT HIQEIVEKFG LVCVSRSGHD PERYISDSPI LQQFQHNIHL AREPVLNEIS ATYVRKALGQ GQSVKYLLPE AVITYIRDQG LYINDGSWKG KGKTG
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury.
基因功能參考文獻(xiàn)：
1. NMNAT3 regulates the activity of SIRT3 via synthesis of mitochondria NAD. PMID: 27423420
2. Results indicated that Nmnat3 is dispensable in the maintenance of mitochondrial NAD levels, and that other NAD regulatory pathways may exist in mitochondria. PMID: 26756334
3. Data indicate that nicotinamide mononucleotide adenylyltransferase 3 (Nmnat3)deficiency causes splenomegaly and hemolytic anemia in mice. PMID: 24739386
4. results suggest that axonal protection by NMNAT expression in neurons is provided by modifying mitochondrial functionNMNAT activity does lead to axonal protection phenotype in vivo PMID: 19439605
亞細(xì)胞定位：

Mitochondrion.
蛋白家族：

Eukaryotic NMN adenylyltransferase family
數(shù)據(jù)庫鏈接：

KEGG: mmu:74080

STRING: 10090.ENSMUSP00000035031

UniGene: Mm.294082