Recombinant Mouse Neuropilin and tolloid-like protein 1 (Neto1), partial

中文名稱：

小鼠Neto1重組蛋白
貨號：

CSB-YP823185MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Neto1重組蛋白
貨號：

CSB-EP823185MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Neto1重組蛋白
貨號：

CSB-EP823185MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Neto1重組蛋白
貨號：

CSB-BP823185MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Neto1重組蛋白
貨號：

CSB-MP823185MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Neto1
Uniprot No.：

Q8R4I7
別名：

Neto1; Btcl1; Neuropilin and tolloid-like protein 1; Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory.
基因功能參考文獻：
1. The data of this study showed that a novel role for NETO1 in regulation of axonal Kainate Receptors and identify its physiological significance in development of the CA3-CA1 circuit. PMID: 28680963
2. GluK2 surface and synaptic expression are independent on the auxiliary subunits Neto1 and Neto2. In the CA1 hippocampal pyramidal cell, GluK2, in contrast to GluK1, traffics to the neuronal surface and synapse efficiently and the auxiliary subunits rNeto1 and mNeto2 caused no further enhancement of these 2 trafficking processes. PMID: 28100490
3. These results confirm that Neto protein interactions regulate synaptic localization of NMDA and kainate receptor subunits at mossy fiber-CA3 pyramidal cell synapses. PMID: 24403160
4. This study demonistrated that Neto1 to regulate both NMDARs and KARs reveals a unique dual role in controlling synaptic transmission by serving as an auxiliary protein for these two classes of ionotropic glutamate receptors in a synapse-specific fashion. PMID: 21734292
5. The results of this study indicated that two distinctive properties of native kainate receptors, their high-affinity binding pattern in the brain and slow kinetics at postsynapses, are conferred by the kainate receptors auxiliary subunit Neto1. PMID: 21623363
6. Assembly with NETO1 and NETO2 differentially modifies homomeric glutamate K1 (GluK1) kainate receptor gating. PMID: 21593317
7. Data describe the isolation and characterization of a novel gene, Btcl1 (brain-specific transmembrane protein containing two CUB and an LDLa domains), which has significant homology with neuropilin-1 and -2 in their CUB domains. [Btcl1] PMID: 12810072
8. Neto1 regulates NMDA receptor-dependent synaptic plasticity and cognition. PMID: 19243221
9. Focuses mainly on human NETO1 but also describes identification of mouse Neto1. PMID: 11943477
顯示更多

收起更多
亞細胞定位：

Membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic density membrane. Note=Component of the postsynaptic density (PSD) of excitatory synapses.
組織特異性：

Expressed only in brain. Present throughout the central nervous system. Highly expressed in the hippocampal CA3 region, olfactory bulb and tubercle, caudate putamen, and neocortex in the adult brain.
數據庫鏈接：

KEGG: mmu:246317

STRING: 10090.ENSMUSP00000057340

UniGene: Mm.329578