Recombinant Mouse Neural cell adhesion molecule 1 (Ncam1), partial

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中文名稱：

小鼠Ncam1重組蛋白
貨號：

CSB-EP015511MO
說明書：

MSDS Datasheet
規格：

￥2532
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 85% as determined by SDS-PAGE.
生物活性：

Not Test
基因名：

Ncam1
Uniprot No.：

P13595
別名：

N-CAM-1;NCAM-1;CD antigen CD56
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
來源：

E.coli
分子量：

76.8 kDa
表達區域：

20-711aa
氨基酸序列

LQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTLTIYNANIDDAGIYKCVVTAEDGTQSEATVNVKIFQKLMFKNAPTPQEFKEGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTVQARQSIVNATANLGQSVTLVCDADGFPEPTMSWTKDGEPIENEEEDDEKHIFSDDSSELTIRNVDKNDEAEYVCIAENKAGEQDASIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEFQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDRVEPYSSTAQVQFDEPEATGGVPILKYKAEWKSLGEESWHFKWYDAKEANMEGIVTIMGLKPETRYSVRLAALNGKGLGEISAATEFKTQPVREPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVKYRALASEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTAGLST
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

Tag-Free
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
基因功能參考文獻：
1. PrP and ZIP6 inherited the ability to interact with NCAM1 from their common ZIP ancestors but have since diverged to control distinct posttranslational modifications of NCAM1. PMID: 28098160
2. inhibiting NCAM1 would be cardioprotective, counteract the pathological action of TGFbeta1 and reduce heart failure severity. PMID: 28870505
3. NCAM deletion in young adult mice reduces recovery after spinal cord injury. PMID: 27178448
4. the neural cell adhesion molecule NCAM is co-expressed and directly interacts with GFRalpha1 in embryonic Purkinje cells. PMID: 28076782
5. Increased polysialylation of the NCAM has been found in a transgenic mouse model of sialuria. PMID: 27966821
6. study delineates a mechanism in which NCAM promotes ephrin-A5-dependent clustering of EphA3 through interaction of the NCAM Ig2 domain and the EphA3 CRD, stimulating EphA3 autophosphorylation and RhoA signaling necessary for growth cone repulsion in GABAergic interneurons in vitro, which may extend to remodeling of axonal terminals of interneurons in vivo. PMID: 27803162
7. data provided molecular details about the interaction between HuPrP and the NCAM fibronectin domain, and revealed a new role of PrP(C) N terminus as a dynamic and functional element responsible for protein-protein interaction. PMID: 27535221
8. Results demonstrate that the early development of calbindin-positive periglomerular interneurons depends on the presentation of polysialic acid on NCAM and requires the activity of both St8sia2 and St8sia4 PMID: 26153130
9. NCAM plays significant roles in the adult visual system in establishing normal retinal anatomy, physiology and function, and in maintaining vision during aging. PMID: 27103522
10. The data of this study demonstrated the importance of NCAM for the development and functional activity of the BDNF signaling and serotonergic neurotransmission PMID: 26499173
11. PrP-deficient cells fail to undergo NCAM1 polysialylation during EMT. PMID: 26288071
12. NCAM-140 significantly promoted cell proliferation, motility and migration, while polysialylation of NCAM-140 catalyzed by STX, but not by PST, enhanced NCAM-mediated cell migration, but not cell proliferation or motility. PMID: 25885924
13. changes of NCAM expression in the late postnatal and mature forebrain determine avoidance behaviour and serotonin (5-HT)1A receptor signalling. PMID: 24751161
14. Dicer ablation in the early metanephric mesenchyme results in severe renal dysgenesis despite normal initial specification of nephron progenitors and ureteric bud outgrowth. PMID: 24500693
15. The molecular clock governs rhythmic ncam1 alpha1-2-fucosylation in secondary olfactory neurons. PMID: 25384980
16. PrP plays a critical role in neuronal differentiation of neuralprecursor cells and suggest that this function is, at least in part, NCAM-dependent. PMID: 24497115
17. This study propose that presynaptic NCAM bridges a critical link between the SV cycle and the functional expansion of synaptic territory through the regulation of L-VDCCs. PMID: 25100585
18. findings suggest that NCAM-mediated processes are involved in both novelty/stress-related emotional behavior and in cognitive function during spatial learning PMID: 24000815
19. findings support involvement of NCAM in regulation of emotional and aggressive behaviors, suggesting that diminished NCAM expression might be a critical vulnerability factor for development of these behavioral alterations under repeated exposure to stress PMID: 24010949
20. The presynaptic endocytotic machinery remains immature in adult NCAM-deficient (NCAM-/-) mice accumulating AP-3 instead of AP-2 and its partner protein AP180 in synaptic membranes and vesicles. PMID: 24133283
21. Intragenic epigenetic changes modulate NCAM alternative splicing in neuronal differentiation. PMID: 23892457
22. The data of this study indicated that reduced NCAM expression in the forebrain might be a critical factor for the occurrence of cognitive impairments during aging. PMID: 23504516
23. These results reveal a new mechanism in which NCAM and ephrinAs/EphA3 coordinate to constrain GABAergic interneuronal arborization and perisomatic innervation. PMID: 22275477
24. In contrast to NCAM-deficient mice, NCAM+/- heterozygotic animals do not demonstrate memory impairment in either object recognition or contextual fear conditioning tests. PMID: 22361116
25. Results indicate that the polySTs ST8SiaII and ST8SiaIV not only recognize an acidic patch in the FN1 domain of NCAM but also must contact sequences in the Ig5 domain for polysialylation of Ig5 N-glycans to occur. PMID: 23341449
26. Our combined observations thus indicate that NCAM activates Pak-1 to drive actin polymerization to promote neuronal differentiation PMID: 23303955
27. alterations in PSA-NCAM levels were seen in the cerebral cortex immediately after injury, and these reductions persisted in brain regions distal to the primary injury site PMID: 22848850
28. The findings indicate that diminished NCAM expression might be a critical vulnerability factor for the development of behavioral alterations by stress and further support a functional involvement of NCAM in stress-induced cognitive and emotional disturbances. PMID: 21939373
29. NCAM deficiency impairs mesenchymal stromal cell motility. PMID: 22683856
30. NCAM180 regulates Ric8A membrane localization and potentiates beta-adrenergic response PMID: 22384181
31. An abnormally high rate of postsynaptic membrane endocytosis may thus contribute to brain pathologies associated with mutations in NCAM or spectrin. PMID: 21339376
32. data suggest that affecting homeostasis of NCAM polysialylation may lead to alterations in precise neuronal circuit formation PMID: 22068610
33. In twelve-month-old NCAM-deficient (but not NCAM-positive) mice, hippocampal long-term potentiation is impaired by comparison with 3-month-old mice that could be rescued by d-cycloserine, a GluN2A agonist. PMID: 22396402
34. N-CAM exhibits a regulatory function in pathological angiogenesis in oxygen induced retinopathy. PMID: 22043302
35. The polysialylated form of Ncam appears to provide a mechanism for modulation of chronic sensory overload, by means of attenuation of the activity of the NCAM-180 isoform, which reduces nociceptive transmission. PMID: 22200540
36. Plannexin facilitates neurite outgrowth in primary hippocampal neuronal cultures and improves spatial learning under conditions involving a deficit in a key plasticity-promoting posttranslational modification of NCAM, its polysialylation. PMID: 21887252
37. these findings show a co-localization of NCAM and FGFR2 in early vertebrate development with intracellular signaling pathways present to enable a cellular response PMID: 21710437
38. results suggest a novel role of NCAM in promoting insulin signaling and adipocyte differentiation of adult stem cells. PMID: 21730021
39. Immobilized pool of NCAM180 in the postsynaptic membrane is homeostatically replenished by the flux of NCAM180 from extrasynaptic regions. PMID: 21550975
40. NCAM potentiates cellular invasion and metastasis of melanoma cells through stimulation of PKA and PI3K signaling pathways PMID: 21277992
41. we reveal a novel role for NCAM in that it regulates addition of the new membrane to the cell surface of growth cones in developing neurons. PMID: 21389209
42. (polysialic acid)In embryonic stem cells overexpressing polysialic acid there is an enhanced chemotatic migration towards gradients of chemoattractants. PMID: 17823239
43. NCAM-dependent rearrangements of the membrane associated spectrin meshwork via caspase-8 dependent caspase-3 activation are thus indispensable for NCAM-mediated neurite outgrowth PMID: 20961848
44. analysis of cytolytic CD56(dim)CD16+ NK cells as rapid producers of abundant IFN-gamma on activation PMID: 21187373
45. NCAM in the amygdala mediates consolidation of auditory fear conditioning; increased NCAM expression in the amygdala is among the mechanisms whereby stress facilitates fear conditioning processes. PMID: 20059553
46. NCAM mediates cell recognition processing of amygdalo-hippocampal system modulation of contextual fear memory. PMID: 20003620
47. The alteration of neuronal remodeling proteins in the hippocampus may be an underlying mechanism of venlafaxine in treating post-stroke depression. PMID: 20651837
48. NCAM-mediated pathways may be involved in the activation of extracellular signal-regulated MAP kinases at acute stages and upregulation of GAP-43 expression to promote cell survival, regenerated axons, synaptogenesis, and function recovery. PMID: 20381564
49. A novel interaction was identified between NCAM and spike protein and this association is critical during porcine hemagglutinating encephalomyelitis virus infection. PMID: 20863409
50. NCAM is a cardioprotective factor up-regulated under metabolic stress in cardiomyocytes PMID: 19853610
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亞細胞定位：

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell membrane; Lipid-anchor, GPI-anchor.
數據庫鏈接：

KEGG: mmu:17967

STRING: 10090.ENSMUSP00000130668

UniGene: Mm.439182