Recombinant Mouse NF-kappa-B-activating protein (Nkap)

中文名稱：

小鼠Nkap重組蛋白
貨號(hào)：

CSB-YP887486MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Nkap重組蛋白
貨號(hào)：

CSB-EP887486MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Nkap重組蛋白
貨號(hào)：

CSB-EP887486MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Nkap重組蛋白
貨號(hào)：

CSB-BP887486MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Nkap重組蛋白
貨號(hào)：

CSB-MP887486MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Nkap
Uniprot No.：

Q9D0F4
別名：

Nkap; NF-kappa-B-activating protein
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-415
氨基酸序列

MAPVSGSRSP EREASGAKRR SPSRSPKSIK SSRSPRCRRS RSRSCSRFGD RNGLSHSLSG FSQSSRNQSY RSRSRSRSRE RPSAQRSAPF ASASSSAYYG GYSRPYGGDK PWPSLLDKER EESLRQKRLS ERERIGELGA PEVWGLSPKN PEPDSDEHTP VEDEEPKKST TSASSSEDDK KKKRKSSHSK DRAKKKRKKK SSKRKHKKYS EDSDSDSESD TDSSDEDSKR RAKKAKKKDK KKKRRGKKYK KKKSKKNRKE SSDSSSKESQ EEFLENPWKD RSKAEEPSDL IGPEAPKTLA SQDDKPLNYG HALLPGEGAA MAEYVKAGKR IPRRGEIGLT SEEIASFECS GYVMSGSRHR RMEAVRLRKE NQIYSADEKR ALASFNQEER RKRENKILAS FREMVYRKTK GKDDK
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter.
基因功能參考文獻(xiàn)：
1. NKAP regulates multiple steps in Invariant NKT cell development and differentiation. PMID: 27183586
2. we provide first evidence for the expression of NKAP in neurogenic cells of the adult mammalian brain PMID: 24583034
3. Transcriptional repressor NKAP is required for invariant natural killer T cell but not conventional T cell development. PMID: 23481390
4. NKAP is required for T cell maturation and the acquisition of functional competency PMID: 21624937
5. Inducible deletion of NKAP in adult mice leads to lethality within 2 weeks, at which point hematopoiesis in the bone marrow has halted and hematopoietic stem cells have disappeared. PMID: 20610818
6. NKAP is a novel nuclear regulator of TNF- and IL-1-induced NF-kappaB activation PMID: 14550261
7. NKAP functions as a transcriptional repressor, acting on Notch target genes, and is required for alphabeta T cell development. PMID: 19409814
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亞細(xì)胞定位：

Nucleus.
蛋白家族：

NKAP family
數(shù)據(jù)庫鏈接：

KEGG: mmu:67050

STRING: 10090.ENSMUSP00000016553

UniGene: Mm.55422