Recombinant Mouse N-acetylglutamate synthase, mitochondrial (Nags)

中文名稱：

小鼠Nags重組蛋白
貨號：

CSB-YP837149MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Nags重組蛋白
貨號：

CSB-EP837149MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Nags重組蛋白
貨號：

CSB-EP837149MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Nags重組蛋白
貨號：

CSB-BP837149MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Nags重組蛋白
貨號：

CSB-MP837149MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Nags
Uniprot No.：

Q8R4H7
別名：

Nags; N-acetylglutamate synthase; mitochondrial; EC 2.3.1.1; Amino-acid acetyltransferase) [Cleaved into: N-acetylglutamate synthase long form; N-acetylglutamate synthase short form; N-acetylglutamate synthase conserved domain form]
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

19-527
氨基酸序列

LR SPGGPGGSRR LSGSARRRGA KSASPGRRLS TARAHAEDAE GAKGRVQSPA VEEPSWTPLP TPLESPAPPA GRSLVQRDIQ AFLNQCGASP GEARHWLTQF QTCYHSVDKP FAVMEVDEEV IRCPQAVSRL AFALAFLQRM DMKPLVVLGL PTPTAPSGCL SFWEAKAQLA QSCKVLVDEL RHNAATAVPF FGGGSVLSAA EPAPHASYGG IVAVETDLLQ WCLESNSIPI LCPIGETAAR RSVLLDSLEV TASLAKALQP TKIIFLNNSG GLRNNSQKIL SNVNLPADLD LVTNAEWLSI KERQQIRLIV DVLSRLPHYS SAVITAASTL LTELFSNKGC GTLFKNAERM LRVRNLDSLD QGRLVNLVNA SFGKKLREDY LESLRPRLHS IYVSEGYNAA AILTVEPVLG GTPYLDKFVV SSSRQGQGSG QMLWECLRRD LQTLFWRSRV TNPINPWYFK HSDGSFSNKQ WIFFWFGLAD IRDSYELVNH AKGLPDSFCK PASDPGS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPS1) activity.
基因功能參考文獻：
1. The specificity of the assay was validated by demonstrating a complete deficiency of NAGS in liver homogenates from Nags -/- mice. CONCLUSION: The novel NAGS enzyme assay reported herein can be used for the diagnosis of inherited NAGS deficiency and may also be of value in the study of secondary hyperammonemia present in various inborn errors of metabolism as well as drug treatment. PMID: 27771289
2. Sp1, CREB, HNF-1, and NF-Y, known to be responsive to hormones and diet, regulate NAGS transcription PMID: 22383952
3. identification, cloning and expression PMID: 12049647
4. Is a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) PMID: 15050968
5. The biochemical properties of purified recombinant human and mouse NAGS-M and NAGS-C were determined in this study with the goal of better understanding the role of the variable domain in NAGS function. PMID: 16321554
顯示更多

收起更多
亞細胞定位：

Mitochondrion matrix.
蛋白家族：

Acetyltransferase family
組織特異性：

Highly expressed in the liver and small intestine. Weakly expressed in the kidney, spleen and testis.
數據庫鏈接：

KEGG: mmu:217214

STRING: 10090.ENSMUSP00000050258

UniGene: Mm.31686