Recombinant Mouse Methionine-R-sulfoxide reductase B3, mitochondrial (Msrb3)

中文名稱：

小鼠Msrb3重組蛋白
貨號：

CSB-YP807407MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Msrb3重組蛋白
貨號：

CSB-EP807407MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Msrb3重組蛋白
貨號：

CSB-EP807407MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Msrb3重組蛋白
貨號：

CSB-BP807407MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Msrb3重組蛋白
貨號：

CSB-MP807407MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Msrb3
Uniprot No.：

Q8BU85
別名：

Msrb3; Methionine-R-sulfoxide reductase B3; mitochondrial; MsrB3; EC 1.8.4.12; EC 1.8.4.14
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區(qū)域：

57-253
氨基酸序列

AAFA SAGDTTAMSA FNLLHLVTKS QPVAPRACGL PSGSCRDKKN CKVVFSQQEL RKRLTPLQYH VTQEKGTESA FEGEYTHHKD PGIYKCVVCG TPLFKSETKF DSGSGWPAFH DVISSEAIEF TDDFSYGMHR VETSCSQCGA HLGHIFDDGP RPTGKRYCIN SASLSFTPAD SSEAEGSGIK ESGSPAAADR AEL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine.
基因功能參考文獻：
1. results provide insight into the role of MsrB3 in hearing function and bring us one step closer to hearing restoration as a fundamental therapy PMID: 26649646
2. data suggest that MsrB3 plays an essential role in maintaining the integrity of hair cells, possibly explaining the pathogenesis of DFNB74 deafness in humans caused by MSRB3 deficiency. PMID: 24191262
3. MsrB3 deficiency activates the cell cycle inhibitors p21 and p27. PMID: 24583268
4. data suggest that, in mice, MsrB3 is largely or exclusively an endoplasmic reticulum-resident protein, and that the reduction of methionine-R-sulfoxides in different cellular compartments is provided by individual MsrB isozymes. [MsrB3] PMID: 15249228
亞細胞定位：

Endoplasmic reticulum. Note=Not detected in the mitochondrion.
蛋白家族：

MsrB Met sulfoxide reductase family
組織特異性：

Widely expressed. Detected in the sensory epithelia of the organ of Corti and vestibular end organs as early as P2 up to adulthood (at protein level). In the organ of Corti, present in inner and outer hair cells and, to a lesser extent, in supporting cell
數(shù)據(jù)庫鏈接：

KEGG: mmu:320183

STRING: 10090.ENSMUSP00000089781

UniGene: Mm.169755