1. mGlu7 may be a potential therapeutic target for multiple aspects of the Rett phenotype. PMID: 28814546
2. The mGlu7 receptor was found to be involved in a wide range of behavioral and physiological alterations in response to chronic psychosocial stress exposure. PMID: 27188844
3. This study provides evidence for mGlu7 receptor-mediated tonic modulation of a physiological function in vivo preventing synchronous and potentially pathological oscillations. PMID: 27199672
4. Analysis of mGluR7 KO mice, c-Fos expression, and cerebral MMPIP microinjection indicate that inhibition of mGluR7 impairs intermale aggression owing to information processing dysfunction within the bed nucleus of the stria terminalis PMID: 26149357
5. muscle does not appear to require high levels of SMN above what is produced by two copies of SMN2 PMID: 26276812
6. SAM68 is a physiological regulator of SMN2 splicing in a spinal muscular atrophy mouse model. PMID: 26438828
7. Hyperoxia treatment increased the inclusion of SMN2 exon 7 in skeletal muscles and resulted in improved motor function. PMID: 22763238
8. Elfn1 recruits mGluR7 to synaptic sites.A trans interaction of Elfn1 and mGluR7 controls targeted interneuron synapse development. PMID: 25047565
9. GRM7 regulates the phosphorylation of CREB protein and the expression of Yes-associated protein (YAP) by directly interacting with CaM, which subsequently regulates the expression of CyclinD1 and ultimately affects early cortical development. PMID: 25921811
10. Modeling the selective interaction between XAP044 and mGlu7's Venus flytrap domain, whose three-dimensional structure is already known, will facilitate future drug development supported by computer-assisted drug design PMID: 24596089
11. The data of this study revealed very different roles for mGlu7 in amygdala synaptic transmission, fear learning and its expression PMID: 23664812
12. These data suggest targeting mGlu7 receptors with selective antagonist drugs may be an effective and safe strategy for the treatment of anxiety disorders. PMID: 23603202
13. Glutamate release mediated by GluR7 at nerve terminals is influenced by divalent calcium channel type Ca2+ ionophore. PMID: 23174341
14. mGluR7, by affecting the cofilin/actin signaling, regulates NMDAR trafficking and function PMID: 22287544
15. The genomic integration site of the mGluR7 transgene is in intron 4 in spinal muscular atrophy transgenic mice, especially those that have extended survival. PMID: 21396450
16. Phorbol esters and prolonged activation of mGlu7 receptors both potentiate glutamate release via a common intracellular signalling pathway that occurs in nerve terminals containing N-type divalent calcium channels. PMID: 21143597
17. This study suggested that mGlu7 receptor is involved in the regulation of GABAergic system activity at the level of GABA synthesised enzymes, specific proteins expressed by GABAergic neurons and metabotropic receptor for GABA. PMID: 20353761
18. mGlu7 receptors may not only regulate the central components of chronic stress, but may also have a role in the regulation of fluid & electrolyte transport which is significantly disrupted in diseases such as IBS, by enhancing colonic secretory activity PMID: 20423346
19. The mGluR7 may play a pivotal role in mechanisms that regulate behavioural responses to aversive states. Therefore, drugs acting at mGluR7 may provide novel treatments for psychiatric disorders such as depression and anxiety. PMID: 12814372
20. genetic ablation of mGluR7 in mice interferes at multiple sites in the neuronal circuitry and molecular pathways implicated in affective disorders. PMID: 16237391
21. mGluR4 and mGluR7 were located close to bipolar cell ribbons PMID: 17311335
22. Metabotropic glutamate receptor 7 (GluR7) is uniquely expressed in dendrites of the ON cone bipolar cell pathway and reveals a unique connection to rod cells. PMID: 17553999
23. gene mapping and gene mRNA expression data in segregating and congenic mice identify glutamate receptor metabotropic 7 (Grm7) as a cis-regulated gene and suggest a role in alcohol consumption PMID: 17936574
24. The observed delays in the acquisition of complicated stimulus associations across conditioning procedures may suggest a critical role for mGluR7 in neurocognitive functions and psychopathology PMID: 18289889
25. group III mGluRs regulate spontaneous glutamate release of terminals projecting to dopamine cells in the ventral tegmental area of mice and this effect is most likely mediated by mGluR7 PMID: 18534761
26. PICK1 binding to the C-terminal region of mGluR7a is crucial for agonist-triggered presynaptic signaling in vivo. PMID: 18716219
27. GRM7 is expressed in the hair cells and in spiral ganglion cells of the inner ear of human and mouse. PMID: 19047183

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KEGG: mmu:108073

STRING: 10090.ENSMUSP00000133957

UniGene: Mm.240881