Recombinant Mouse Metabotropic glutamate receptor 3 (Grm3), partial

中文名稱：

小鼠Grm3重組蛋白
貨號：

CSB-YP865599MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Grm3重組蛋白
貨號：

CSB-EP865599MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Grm3重組蛋白
貨號：

CSB-EP865599MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Grm3重組蛋白
貨號：

CSB-BP865599MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Grm3重組蛋白
貨號：

CSB-MP865599MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Grm3
Uniprot No.：

Q9QYS2
別名：

Grm3; Gprc1c; Mglur3; Metabotropic glutamate receptor 3; mGluR3
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
基因功能參考文獻：
1. the activation of mGluR3 up-regulates the membrane expression of TWIK-1 that in turn enhances NH4(+) uptake in astrocytes. PMID: 26553349
2. Activation of Grm3 ameliorates lupus-like disease in mice by reducing B cell numbers. Grm3 expression on B-cells is decreased in lupus-prone mice. PMID: 26071318
3. The number of mGluR3-immunoractive cells was significantly reduced in the dorsal and intermediate but not ventral parts of the lateral septum in postpartum versus virgin females. PMID: 25739438
4. GRM3-knockout mice exhibit a biphasic effect in spatial working memory, initially impaired but performing better after training. PMID: 25158312
5. The results of these studies implicate mGlu3 as a major regulator of PFC function and cognition. PMID: 25583490
6. This study demonistrated that mGluR3 knockout mice show a working memory defect. PMID: 24631392
7. report we describe a novel neuroprotective function of mGlu3 receptors related to their ability to promote the non-amyloidogenic pathway of APP cleavage in astrocytes, thus enhancing sAPPalpha production PMID: 24291464
8. study found that astrocytic expression of mGluR5 is developmentally regulated and is undetectable after postnatal week 3; mGluR3, whose activation inhibits adenylate cyclase but not calcium signaling, was expressed in astrocytes at all developmental stages PMID: 23307741
9. Restraint stress induces a schizophrenia-like phenotype in mice, with epigenetic changes in mGlu2 and mGlu3 receptors that lie at the core of the pathological programming induced by early-life stress. PMID: 22089319
10. Fractionation of hippocampus-dependent memory depending on the appetitive-aversive context is to our knowledge unique, and suggests a role for group II metabotropic GluRs (mGlu2/3)at the interface of arousal and cognition. PMID: 21832989
11. This study demonistrated that mGluR3 and not mGluR2 receptors mediate the efficacy of NAAG peptidase inhibitor in validated model of schizophrenia. PMID: 22300789
12. Following isolation rearing there is an increase in mGluR3 density in prefrontal cortex and hippocampus. PMID: 20970439
13. These data raise the intriguing possibility that glutamate regulates differentiation of SVZ/NSCs by activating mGlu3 receptors. PMID: 20091783
14. Group III mGluR may be functionally expressed to suppress self-renewal capacity through a mechanism related to cyclic adenosine monophosphate (cAMP) formation with promotion of subsequent differentiation into astroglial lineage in neural progenitors. PMID: 18266930
15. In the hippocampus of mGluR3 knockout mice, glutamate transporters EAAT1 and EAAT2 are decreased. PMID: 18720515
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 3 family
數據庫鏈接：

KEGG: mmu:108069

STRING: 10090.ENSMUSP00000004076

UniGene: Mm.318966