Recombinant Mouse Metabotropic glutamate receptor 2 (Grm2), partial

中文名稱：

小鼠Grm2重組蛋白
貨號：

CSB-YP621804MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Grm2重組蛋白
貨號：

CSB-EP621804MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Grm2重組蛋白
貨號：

CSB-EP621804MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Grm2重組蛋白
貨號：

CSB-BP621804MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Grm2重組蛋白
貨號：

CSB-MP621804MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Grm2
Uniprot No.：

Q14BI2
別名：

Grm2; Gprc1b; Mglur2Metabotropic glutamate receptor 2; mGluR2
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
基因功能參考文獻：
1. Here we show that glutamate signals through metabotropic glutamate receptor 2 (mGluR2) to induce Erk phosphorylation in SC. mGluR2-elicited Erk phosphorylation requires ErbB2/3 receptor tyrosine kinase phosphorylation to limit the signaling cascade that promotes phosphorylation of Erk, but not Akt. PMID: 27432639
2. activation of mGlu2 receptors is detrimental in the post-ischemic phase, and support the use of mGlu2 receptor antagonists in the experimental treatment of brain ischemia. PMID: 28821279
3. mGlu2 activation exerts effects on striatal physiology that extend beyond modulation of corticostriatal synapses, and has the potential to influence cognition and striatum-related disorders via inhibition of thalamus-derived glutamate and dopamine release. PMID: 28159646
4. These studies provide a foundation for future research seeking to parse out the roles of mGlu2 from mGlu3, paving the way for better understanding of how these receptors regulate activity in the brain. PMID: 27818290
5. Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia. PMID: 26758213
6. provided evidence that JARID1B via modulation of stemness-related signaling is a putative novel therapeutic target for treating malignant NB PMID: 25950516
7. Activation of GABA(B) or mGlu2/3 receptors inhibited both evoked presynaptic Ca(2+) transients and striatal field potentials. PMID: 25781000
8. In GRM2 knockout mice motor coordination and cognition is unchanged compared to GRM2/3 double knockout mice. PMID: 25158312
9. activation of both Group I and Group II metabotropic glutamatergic receptors suppress retinogeniculate transmission PMID: 23558090
10. The findings support the possibility that interactions between mGlu2/3 and dopamine may be relevant to the pathophysiology and therapy of schizophrenia and other disorders PMID: 24053122
11. mGluR3 knockouts did not differ from controls in reinstatement of drug-seeking behavior, suggesting that mGluR2 receptors are critical in mediating addictive-like behavior. PMID: 23624743
12. In the central nervous system, mGluR2 and mGluR4 form a hetero-complex with a distinct pharmacological profile. PMID: 24381270
13. The reduction in the expression of mGluR2 and mGluR3 may be involved in the development of benzodiazepine dependence. PMID: 23392308
14. 5-HT(2A) receptor-dependent signaling epigenetically affects mGlu2 transcription in mouse frontal cortex. PMID: 23508685
15. The mGluR2 subtype activates an inwardly rectifying potassium conductance in dendrites of the dentate gyrus. PMID: 23616537
16. L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors. PMID: 23382250
17. Three residues located at the intracellular end of transmembrane domain four are necessary for the mGlu2 receptor binding to 5TR2A. PMID: 23129762
18. Restraint stress induces a schizophrenia-like phenotype in mice, with epigenetic changes in mGlu2 and mGlu3 receptors that lie at the core of pathological programming induced by early-life stress. PMID: 22089319
19. Fractionation of hippocampus-dependent memory depending on the appetitive-aversive context is to our knowledge unique, and suggests a role for group II metabotropic GluRs at the interface of arousal and cognition. PMID: 21832989
20. Isolation rearing causes an increase in mGluR2 receptors in prefrontal cortex and hippocampus. PMID: 20970439
21. Hippocampal mossy fiber long-term depression in Grm2/3 double knockout mice. PMID: 21360593
22. Data show a significant reduction of the inward current in mGluR3(-/-) but not in mGluR2(-/-) mice. PMID: 21628565
23. Formation of a 5-serotonin 5-HT2A receptor (HT2AR)-mGluR2 complex suggests a functional interaction that affects the hallucinogen-regulated cellular signaling pathways. PMID: 21276828
24. Report activity of mGlu2/3 receptor agonist in memantine-induced brain activation. PMID: 21057775
25. In frontal cortex of mice born to influenza virus-infected mothers, the 5-HT(2A) receptor is upregulated and the mGlu(2) receptor is downregulated, an alteration that may be involved in the behavioral changes observed. PMID: 21289196
26. partial, but highly significant, loss of mGlur2 receptors in amyloid-affected discrete brain regions of Alzheimer cases and PS2APP mice PMID: 20875805
27. Experience-dependent plasticity without long-term depression by type 2 metabotropic glutamate receptors in developing visual cortex. PMID: 11805343
28. Constitutively active Galphai2 occludes the transient suppression of synaptic transmission by mGluR2. PMID: 16606834
29. MGlu2 is regulated by the NF-kappaB transcriptional machinery; agents that increase acetylation and activation of NF-kappaB transcription factors induce analgesia via upregulation of mGlu2 in DRG neurons. PMID: 16764720
30. Kainate receptors activation interferes with the depression of glutamate release produced by Group II metabotropic glutamate receptor stimulation PMID: 17510730
31. 2AR and mGluR2, but not mGluR3, are co-expressed in cortical neurons PMID: 18297054
32. In the hippocampus of mGluR2 knockout mice, there is a compensatory upregulation of other glutamate receptors and a downregulation of glutamate transporter expression. PMID: 18720515
33. major role played by the dentate gyrus and CA3 areas in the early phases of contextual memory processing through MGLUR2 AND MGLUR3 PMID: 19638469
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亞細胞定位：

Cell membrane; Multi-pass membrane protein. Cell junction, synapse. Cell projection, dendrite.
蛋白家族：

G-protein coupled receptor 3 family
組織特異性：

Detected in neurons in brain cortex (at protein level).
數(shù)據(jù)庫鏈接：

KEGG: mmu:108068

STRING: 10090.ENSMUSP00000023959

UniGene: Mm.410822