Recombinant Mouse Meckel syndrome type 1 protein homolog (Mks1)

中文名稱：

小鼠Mks1重組蛋白
貨號：

CSB-YP722551MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Mks1重組蛋白
貨號：

CSB-EP722551MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Mks1重組蛋白
貨號：

CSB-EP722551MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Mks1重組蛋白
貨號：

CSB-BP722551MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Mks1重組蛋白
貨號：

CSB-MP722551MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Mks1
Uniprot No.：

Q5SW45
別名：

Mks1Meckel syndrome type 1 protein homolog
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-561
氨基酸序列

MAEAVWSTDT GEAVYRSRDP VRNLRLRVHL QRITSSNFLH YQPAAQMGKD LIDLATFRPP QAASGHRPDE EEEEEVVIGW QEKLFSQFEV DLYQNESACQ SPLDHQYRQE ILKLENSGGR KNRRIFTYTD SDRYTDLEEY CQKITTSASE VPSFLAERMA NVRRRRQDRR GVEGSKLKSR IVTWEPSEDF IKNNHAINTP LQTMYIMADL GPYGKLGYKV HEHVLCILKV DSNGVITVKP DFTGIKGPYR IETEGEKQEH TSAWKYTIDN VSSLAQPEEE EREQRVFKDL YGRHKEYLSS LVGTDFEMIA PGALRLFVNG EVVSAQGYEY DNLYVHFFVE LPAANWSSPP FQQLSGVTQA CATKSLGMDK VAYFSFPFTF EAFFLHEDES AESLPEWPVL YCKVLSLDFW QRYRVEGYGA VVLPATPGSH TLTVSTWRPM ELGLVAELRR FFIGGSLELE DPSYVRIPGT FKGERLSRFG FRTETTGTVT FRLHCLQQSR AFMESNSLQK QMRSVLDRLE GFSQQSSTHN VLEAFRRARR RMQEARESLP QDLVSPTGTL T
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology.
基因功能參考文獻：
1. Dnah11(avc)(4) did not disrupt SHF Hh signaling and caused Atrioventricular septal defects (AVSDs) only concurrently with heterotaxy, a left/right axis abnormality. In contrast, Mks1(avc)(6) disrupted SHF Hh signaling and caused AVSDs without heterotaxy.We speculate that cilia gene mutations contribute to both syndromic and non-syndromic AVSDs in humans PMID: 27340223
2. Centriole localization of Mks1 is required for ciliogenesis of motile and non-motile cilia, but not for centriole assembly. PMID: 21045211
3. Mks1 is required for ciliogenesis and shh signaling in mouse model of human meckel syndrome. PMID: 19776033
4. Mks1 expression in mouse embryos, as determined by in situ hybridization, agrees well with the tissue phenotype of MKS. PMID: 16415886
亞細胞定位：

Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme.
組織特異性：

Widely expressed in embryo at E15.5, with a relatively strong expression in brain, liver, kidney and digits of the upper limbs. Highly expressed in bronchiolar epithelium.
數據庫鏈接：

KEGG: mmu:380718

STRING: 10090.ENSMUSP00000043790

UniGene: Mm.24404