Recombinant Mouse McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin (Mkks)

中文名稱：

小鼠Mkks重組蛋白
貨號：

CSB-YP888304MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Mkks重組蛋白
貨號：

CSB-EP888304MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Mkks重組蛋白
貨號：

CSB-EP888304MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Mkks重組蛋白
貨號：

CSB-BP888304MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Mkks重組蛋白
貨號：

CSB-MP888304MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Mkks
Uniprot No.：

Q9JI70
別名：

Mkks; Bbs6; McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin; Protein Bbs6 homolog
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-570
氨基酸序列

MSRLEAKKPS LCKTEPLTSE KVRSTLSVLK GVIASCYGPS GRLKQLHNGL GGCVYTTSQS SALLRNLSVT HPVLKILTSS VQNHVSCFSD CGLFTAILCC NLIENIQRLD LTPATAIKLN KYLLSLCTSY LKSEACSCRI PVDFRSTHTF LSLVHSILTS KPACMLTRKE TDHIGALILK AFLLTIPEST EERMVLGKSI IVPLKGQRVT DSTVLPGLLI EASEVQLRRL LPTQKASGLR VALFCTSLSG DFSNAGEGVV VAHYQVSLEN AVLEQLLNLG RRLVTDHVDL VLCQKVIHPS LKQFFSERHV MAIDRVGVTL MESLSKVTGA TPIGSLNPIV STTYGSVKDV CSARFGSKHF FHLLPNEATV CTLLLCSRND TAWEELKLTC QTAMHVLQLT IKEPWVLLGG GCTETHLAAY VRHKVHHEAE AIVRDDGCTQ AKLHVAAEAF CSALESVAGS LEHDGGEILI DTKYGHLWSC QADSASVGNW SDTLSRCGCG LYNSQEELSW SVLRSTYHPF APQTCLPQAA LGSASNLTVD CFTAKLSGLQ VAVETANLIL DLSYVIEDKN
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis. Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis.
基因功能參考文獻：
1. Three uORFs (uMKKS0, uMKKS1 and uMKKS2) are reported, and they can repress the translation of the downstream MKKS ORF. uMKKS1 and uMKKS2 are highly conserved in mammals and they encode two different mitochondrial membrane proteins respectively. PMID: 23671934
2. Combinations of Cep290rd16 & Mkksko alleles improved ciliogenesis & sensory functions vs either mutant alone. Altered association of CEP290 & MKKS affects multiprotein complex integrity at the cilia transition zone & basal body. PMID: 22446187
3. Data implicate Bardet-Biedl syndrome genes in the regulation of vascular function and demonstrate that disrupting Bbs2 and Bbs6 genes affect differentially the vascular function. PMID: 20852044
4. MKKS/BBS6 is a novel centrosomal component required for cytokinesis PMID: 15731008
5. Mutations in Mkks are the basis of the BBS-like syndrome in knockout mice. PMID: 15772095
6. These results indicate that the MKKS mutants have an abnormal conformation and that chaperone-dependent degradation mediated by CHIP is a key feature of McKusick-Kaufman syndrome/Bardet-Biedl syndrome diseases. PMID: 18094050
7. Bardet-Biedl syndrome (BBS) proteins mediate LepR trafficking and that impaired LepR signaling underlies energy imbalance in BBS. PMID: 19150989
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亞細胞定位：

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Nucleus.
蛋白家族：

TCP-1 chaperonin family
組織特異性：

Widely expressed in adult and fetal tissues. Expressed in the developing heart, brain retina, limb buds, as well as in the developing neural tube. Expressed in the embryo in the first and second branchial arches. Expressed in parafin embedded tissue secti
數據庫鏈接：

KEGG: mmu:59030

STRING: 10090.ENSMUSP00000028730

UniGene: Mm.272570