Recombinant Mouse Male-specific lethal 1 homolog (Msl1)

中文名稱：

小鼠Msl1重組蛋白
貨號：

CSB-YP747470MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Msl1重組蛋白
貨號：

CSB-EP747470MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Msl1重組蛋白
貨號：

CSB-EP747470MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Msl1重組蛋白
貨號：

CSB-BP747470MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Msl1重組蛋白
貨號：

CSB-MP747470MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Msl1
Uniprot No.：

Q6PDM1
別名：

Msl1; Msl1l1; Male-specific lethal 1 homolog; MSL-1; Hampin; Male-specific lethal 1-like 1; MSL1-like 1; Male-specific lethal-1 homolog 1
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-616
氨基酸序列

MTMRSAVFKA AAAPAGGNPE QRLDYERAAA LGGPEDESGA AEAHFLPRHR KLKEPGPPLA SSQGGSPSPS PAGCGGGKGR GLLLPAGAAP GQQEESWGGS VPLPCPPPAT KQAGIGGEPV AAGAGCSPRP KYQAVLPIQT GSIVVAAAKE PTPWAGDKGG AAPPAATASD PAGPPPLPLP GPPPLAPTAT AGTLAASEGR WKSIRKSPLG GGGGSGASSQ AACLKQILLL QLDLIEQQQQ QLQAKEKEIE ELKSERDTLL ARIERMERRM QLVKRDNEKE RHKLLQGYEP EEREEAELSE KIKLERQPEL CETSQALPSK PFSCGRSGKG HKRKTPFGNT ERKTPVKKLA PEFSKVKTKT PKHSPIKEEP CGSISETVCK RELRSQETPE KPRSSVDTPP RLSTPQKGPS THPKEKAFSS EMEDLPYLST TEMYLCRWHQ PPPSPLPLRE SSPKKEETVA RCLMPSSVAG ETSVLAVPSW RDHSVEPLRD PNPSDILENL DDSVFSKRHA KLELDEKRRK RWDIQRIREQ RILQRLQLRM YKKKGIQESE PEVTSFFPEP DDVESLLITP FLPVVAFGRP LPKLAPQNFE LPWLDERSRC RLEIQKKHTP HRTCRK
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-5' (H3K4me) and 'Lys-80' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation. Isoform 2, isoform 3, isoform 4 and isoform 5 can medite histone H4 acetylation at 'Lys-16' (H4K16ac).
基因功能參考文獻：
1. Data show that complete removal of paternally expressed gene 3 (PEG3) resulted in up-regulation of male-specific lethal 1 (Msl1) and male-specific lethal 3 (Msl3). PMID: 28609438
2. Msl1 interacts with Msl3 as an extended chain forming an extensive hydrophobic interface, whereas the Msl1-MOF interface involves electrostatic interactions between the HAT domain and a long helix of Msl1. PMID: 21217699
3. hampin may be linked to diverse regulatory processes in the nucleus PMID: 17335777
4. Describes the primary structure of the protein hampin, which shares about 26% sequence identity with the Drosophila MSL1 protein. In mouse, at least five splice isoforms exist, two of which have restricted tissue specificity (testes). PMID: 16119455
亞細胞定位：

Nucleus.; [Isoform 1]: Nucleus. Nucleus speckle.; [Isoform 2]: Nucleus. Nucleus speckle.; [Isoform 3]: Nucleus. Nucleus, nucleoplasm.; [Isoform 4]: Nucleus, nucleoplasm.; [Isoform 5]: Nucleus, nucleoplasm.
蛋白家族：

Msl-1 family
組織特異性：

Isoform 3 and isoform 5 are testis-specific. Isoform 1 and isoform 4 are ubiquitously expressed. Isoform 2 is expressed at low levels in the testis and brain.
數據庫鏈接：

KEGG: mmu:74026

STRING: 10090.ENSMUSP00000042792

UniGene: Mm.258352