Recombinant Mouse MDS1 and EVI1 complex locus protein EVI1 (Mecom), partial
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中文名稱：小鼠Mecom重組蛋白
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貨號：CSB-EP007864MO-B
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說明書：
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規(guī)格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：
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Uniprot No.：
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別名：Mecom; Evi1; Mds1; Prdm3Histone-lysine N-methyltransferase MECOM; EC 2.1.1.-; Ecotropic virus integration site 1 protein; EVI-1; MDS1 and EVI1 complex locus protein; Myelodysplasia syndrome 1 protein homolog
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種屬：Mus musculus (Mouse)
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蛋白長度：Partial
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
靶點詳情
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功能：Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.; Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation.
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基因功能參考文獻：
- These findings highlight a novel mechanism for hepatitis B virus X-induced hepatocarcinogenesis through transcription factor EVI1 and its target lncRNAs PMID: 26967394
- Gata2 heterozygous deletion confers selective advantage to EVI1-expressing leukemia cell expansion in recipient mice PMID: 28630119
- EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias. PMID: 28391050
- Survivin partially regulates HSC function by modulating the Evi-1 transcription factor and its downstream targets PMID: 24903482
- Thrombopoietin/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia. PMID: 25298035
- Prdm16 and Prdm3 control postnatal BAT identity and function. PMID: 24703692
- Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects. PMID: 24586749
- Lack of ME leads to a complex defect in both osseous and non-osseous musculoskeletal tissues. PMID: 24316420
- PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL) fusion protein (MFP) leukemia PMID: 24021671
- Cotransduction of Evi1 and the shortest isoform of C/EBPbeta, liver inhibitory protein (LIP), induced acute myeloid leukemia with short latencies in a mouse bone marow transplantation model. PMID: 23547050
- Transient Evi1 transfection inhibited TGF-beta-induced transcriptional activity and reversed the growth inhibitory effect of TGF-beta in MC-26 mouse colon cancer cells. PMID: 22161860
- Evi1 is a key regulator of adipogenic competency PMID: 22473998
- Data identify Prdm3 and Prdm16 as H3K9me1 methyltransferases and expose a functional framework in which anchoring to the nuclear periphery helps maintain the integrity of mammalian heterochromatin. PMID: 22939622
- EVI1 is a critical player in tumor growth in a subset of MLL-rearranged acute myeloid leukemia. PMID: 22553314
- our study provides important insights into the novel role for EVI1 in negatively regulating NF-kappaB-dependent inflammation PMID: 22581859
- the results indicate that Evi-1 is expressed in a stage-specific manner during ovarian follicular development and may be involved in early follicle development. PMID: 21397932
- Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity. PMID: 22084405
- Results clearly demonstrate a critical role of PR-domain-containing Mds1-Evi1 in linking p57-kip2 regulation to long-term hematopoietic stem cell function. PMID: 21666053
- Evi-1 is one of the targets of MLL oncoproteins and is selectively activated in hematopoietic stem cell-derived MLL leukemic cells. PMID: 21190993
- the silencing of miRNA-124 by DNA methylation is associated with EVI1 expression. PMID: 20448201
- Evi1 represses transcription of caIII gene expression, leading to increased sensitivity to H(2)O(2)-induced apoptosis PMID: 20015077
- EVI1 promotes cell proliferation by interacting with BRG1 and blocking the repression of BRG1 on E2F1 activity PMID: 14555651
- Evi1 directly binds to GATA-2 promoter as an enhancer.GATA-2 is presumably one of critical targets for Evi1 and that transcription factors regulate the hematopoietic stem cell pool hierarchically. PMID: 15889140
- Data demonstrate that the N-terminal DNA binding domain of EVI1 can bind to endogenous genes, and that these genes play a critical role in EVI1-induced transformation. PMID: 16006653
- This report describes a new murine Evi1 gene transcript (Delta105) that contains two alternatively spliced regions encoding a 9 amino acid insertion (Rp+9) within the repressor domain (Rp) and a 105 amino acid C-terminal truncation. PMID: 17014970
- The identification and characterization of the Junbo mutant elaborates a novel role for Evi1 in mammalian disease and implicates a new pathway in genetic predisposition to otitis media. PMID: 17029558
- review of EVI1 expression, biochemical properties, and biological functions [review] PMID: 17507183
- it is concluded that EVI1 has a role in prolonging self-renewal potential of hematopoietic cells & that this ability of EVI1 is limited & modulated by inherent characteristics of the cells PMID: 17913523
- GATA6 and Evi-1 are highly expressed early during cardiogenesis of ES cells, suggesting that they may regulate expression of the calreticulin gene during cardiac development. PMID: 18303859
- observed leukemic progression of six distinct clones harboring gamma-retroviral long terminal repeat or SIN vector insertions in Evi1 or Prdm16, two functionally related genes PMID: 18496560
- Evi1 acts as a transcriptional repressor when recruited to an active promoter, yet through methyl-CpG binding domain protein 3 (Mbd3) interaction it inhibits the histone deacetylation function of this multiprotein structure. PMID: 18500823
- Evi-1 is a common and critical regulator essential for proliferation of embryonic/adult hematopoietic stem cells and transformed leukemic cells. PMID: 18682242
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亞細胞定位：Nucleus. Nucleus speckle. Cytoplasm.
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