Recombinant Mouse Lysine-specific demethylase 4A (Kdm4a), partial

中文名稱：

小鼠Kdm4a重組蛋白
貨號：

CSB-YP804868MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Kdm4a重組蛋白
貨號：

CSB-EP804868MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Kdm4a重組蛋白
貨號：

CSB-EP804868MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Kdm4a重組蛋白
貨號：

CSB-BP804868MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Kdm4a重組蛋白
貨號：

CSB-MP804868MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Kdm4a
Uniprot No.：

Q8BW72
別名：

Kdm4a; Jhdm3a; Jmjd2; Jmjd2a; Kiaa0677Lysine-specific demethylase 4A; EC 1.14.11.-; JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.
基因功能參考文獻：
1. Jmjd2 class demethylases are critical epigenetic regulators involved in etiopathology of depression and related disorders. PMID: 27711046
2. High Jmjd2a expression is associated with neuropathic pain. PMID: 29054488
3. This study dissects an important dual role for maternal Kdm4a in determining faithful early embryonic development and the implantation process. PMID: 28827393
4. We propose the inhibition of KDM4A activity as a strategy to suppress IL-6 production and attenuate colitis induction. PMID: 28511912
5. these data reveal a JMJD2A/ETV1/YAP1 axis that promotes prostate cancer initiation and that may be a suitable target for therapeutic inhibition. PMID: 26731476
6. As well as three novel motifs in JMJD2A-regulated genes. PMID: 25193078
7. Overexpression of KDM4 proteins induces numerous oncogenic effects. (Review) PMID: 24219278
8. JMJD2A bound to the FHL1 promoter in response to TAC, upregulated FHL1 expression, and downregulated H3K9 trimethylation. JMJD2A promotes cardiac hypertrophy under pathological conditions by a novel mechanism. PMID: 21555854
9. JHDM3A(GFP)(701) is a suitable catalytic module that can be targeted, under the control of a guide protein, to specific loci where the chromatin H3K9me3 status and the milieu of gene expression are to be modified. PMID: 21148561
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亞細胞定位：

Nucleus.
蛋白家族：

JHDM3 histone demethylase family
組織特異性：

Widely expressed.
數據庫鏈接：

KEGG: mmu:230674

STRING: 10090.ENSMUSP00000095524

UniGene: Mm.234234