Recombinant Mouse Leupaxin (Lpxn)

中文名稱：

小鼠Lpxn重組蛋白
貨號：

CSB-YP013068MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Lpxn重組蛋白
貨號：

CSB-EP013068MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Lpxn重組蛋白
貨號：

CSB-EP013068MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Lpxn重組蛋白
貨號：

CSB-BP013068MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Lpxn重組蛋白
貨號：

CSB-MP013068MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Lpxn
Uniprot No.：

Q99N69
別名：

Lpxn; Leupaxin
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-386
氨基酸序列

MEELDALLEE LERCTFQDSE EYSNPVSCHL DQQSTEESKI PQTPKTLSSQ GNTSPLKVQL VYATNIQEPN VYSEVQEPKE SVLPPKTSAA AQLDELMAHL SEMQAKVSVK ADTSRKPLPD QQDHKASLDS MLGDLEQELQ DLGIATVPKG YCASCQKPIA GKVIHALGQS WHPEHFVCTH CKEELGSSPF FERSGLAYCS KDYHRLFSPR CAYCAAPITD KVLTAMNKTW HPEHFFCSHC GEVFGAEGFH EKDKKPYCRK DFLAMFSPKC GGCNRPVLEN YLSAMNTVWH PECFVCGDCF SSFSSGSFFE LDGRPFCELH YHHRRGTLCH DCGQPITGRC ISAMGHKFHP EHFVCAFCLT QLPKGIFKEQ NNKTYCEKCF TKLFSQ
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.
基因功能參考文獻：
1. leupaxin functions as a paxillin counterpart that potently suppresses the tyrosine phosphorylation of paxillin during integrin signaling. PMID: 19917054
2. leupaxin may be a critical nucleating component of the osteoclast podosomal signaling complex PMID: 12674328
3. Association of the scaffold protein LPXN with Src adds further complexity to the organization of the podosomal signaling complex in osteoclasts. PMID: 16914530
4. Leupaxin plays an inhibitory role in BCR signaling and B cell function. PMID: 17640867
5. Leupaxin is enriched in mouse vascular smooth muscle and its expression is dynamically regulated during development. PMID: 18497331
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亞細胞定位：

Cytoplasm. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region. Cell projection, podosome. Cell membrane.
蛋白家族：

Paxillin family
組織特異性：

Expressed in osteoclasts (at protein level). Highly expressed in vascular smooth muscle.
數據庫鏈接：

KEGG: mmu:107321

STRING: 10090.ENSMUSP00000025601

UniGene: Mm.313136