Recombinant Mouse Keratin, type II cytoskeletal 2 epidermal (Krt2)

中文名稱：

小鼠Krt2重組蛋白
貨號：

CSB-YP668846MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Krt2重組蛋白
貨號：

CSB-EP668846MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Krt2重組蛋白
貨號：

CSB-EP668846MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Krt2重組蛋白
貨號：

CSB-BP668846MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Krt2重組蛋白
貨號：

CSB-MP668846MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Krt2
Uniprot No.：

Q3TTY5
別名：

Krt2; K2e; Krt2-17; Krt2a; Keratin; type II cytoskeletal 2 epidermal; Cytokeratin-2e; CK-2e; Epithelial keratin-2e; Keratin-2 epidermis; Keratin-2e; K2e; Type-II keratin Kb2
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區(qū)域：

1-707
氨基酸序列

MSCQISCRSR RGGGGGGGGG FRGFSSGSAV VSGGSRRSNT SFSCISRHGG GRGGSGGGGF GSQSLVGLGG YKSISSSVAG NSGGYGGSSF GGSSGFGGGR GFGGGQGFGG SGGFGGGSGF GGGQGFGGGS RFGGGSGFGG GGFGGGSFGG GRFGGGPGGF GGPGGFPGGG IHEVSVNQSL LQPLDVKVDP EIQNVKSQER EQIKTLNNKF ASFIDKVRFL EQQNQVLRTK WELLQQLDVG SRTTNLDPIF QAYIGMLKKQ VDRLSAERTS QESELNNMQD LVEDFKKKYE DEINKRTSAE NDFVTIKKDV DSCYMDKTEL QARLDILAQE VNFLRTLYDA ELSQLQQDVT DTNVILSMDN NRNLDLDSII AEVQNQYEMI AHKSKAESEE LYHSKYEELQ VTAVKHGDSL KEIKMEISEL NRTIQRLQGE ISHVKKQCKG VQDSIADAEQ RGEHAIKDAR GKLTDLEEAL QQCREDLARL LRDYQELMNT KLSLDVEIAT YRKLLEGEEC RMSGDFSDNV SVSITSSTIS SSVASKTGFG SGGQSSGGRG SYGGRGGGGG GGSTYGSGGR SSGSRGSGSG SGGGGYSSGG GSRGGSGGGY GSGGGSRGGS GGGYGSGGGS GSGGGYSSGG GSRGGSGGGG VSSGGGSRGG SSSGGGSRGG SSSGGGGYSS GGGSRGGSSS GGAGSSSEKG GSGSGEGCGS GVTFSFR
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin.
基因功能參考文獻：
1. Loss of keratin K2 expression causes aberrant aggregation of K10, hyperkeratosis, and inflammation. PMID: 24751727
2. increased CK2/SIRT1 expression by cilostazol can be a therapeutic strategy to suppress the tau-related neurodegeneration in the Alzheimer's disease brain PMID: 24254769
相關(guān)疾病：

Defects in Krt2 are a cause of ichthyosis bullosa of siemens (IBS). IBS is a rare autosomal dominant disorder displaying a type of epidermolytic hyperkeratosis characterized by extensive blistering from birth. Hyperkeratoses and shedding of the outer layers of the epidermis (molting) are observed in later weeks.
蛋白家族：

Intermediate filament family
組織特異性：

Expressed predominantly in the suprabasal layers of the plantar epidermis outside of the footpads (at protein level). Expressed mainly in the middle spinous and granular cells of the epidermis of adult tail, nipple and footsole skin. Also found in ear.
數(shù)據(jù)庫鏈接：

KEGG: mmu:16681

STRING: 10090.ENSMUSP00000023712

UniGene: Mm.358616