Recombinant Mouse Kelch-like protein 20 (Klhl20)

中文名稱：

小鼠Klhl20重組蛋白
貨號：

CSB-YP848673MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Klhl20重組蛋白
貨號：

CSB-EP848673MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Klhl20重組蛋白
貨號：

CSB-EP848673MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Klhl20重組蛋白
貨號：

CSB-BP848673MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Klhl20重組蛋白
貨號：

CSB-MP848673MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Klhl20
Uniprot No.：

Q8VCK5
別名：

Klhl20; Kiaa4210; Kleip; Kelch-like protein 20; Kelch-like ECT2-interacting protein
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-604
氨基酸序列

MRRCTNIRPG ETGMDVTSRC TLGDPNKLPE GVPQPARMPY ISDKHPRQTL EVINLLRKHR ELCDVVLVVG AKKIYAHRVI LSACSPYFRA MFTGELAESR QTEVVIRDID ERAMELLIDF AYTSQITVEE GNVQTLLPAA CLLQLAEIQE ACCEFLKRQL DPSNCLGIRA FADTHSCREL LRIADKFTQH NFQEVMESEE FMLLPANQLI DIISSDELNV RSEEQVFNAV MAWVKYSIQE RRPQLPQVLQ HVRLPLLSPK FLVGTVGSDP LIKSDEECRD LVDEAKNYLL LPQERPLMQG PRTRPRKPIR CGEVLFAVGG WCSGDAISSV ERYDPQTNEW RMVASMSKRR CGVGVSVLDD LLYAVGGHDG SSYLNSVERY DPKTNQWSSD VAPTSTCRTS VGVAVLGGFL YAVGGQDGVS CLNIVERYDP KENKWTRVAS MSTRRLGVAV AVLGGFLYAV GGSDGTSPLN TVERYNPQEN RWHTIAPMGT RRKHLGCAVY QDMIYAVGGR DDTTELSSAE RYNPRTNQWS PVVAMTSRRS GVGLAVVNGQ LMAVGGFDGT TYLKTIEVFD PDANTWRLYG GMNYRRLGGG VGVIKMTHCE SHIW
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking. Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11.
基因功能參考文獻：
1. KLEIP is an important molecule regulating corneal epithelial integrity PMID: 22511632
亞細胞定位：

Cytoplasm, perinuclear region. Nucleus. Golgi apparatus, trans-Golgi network. Cell projection, axon. Cell projection, dendrite.
數據庫鏈接：

KEGG: mmu:226541

STRING: 10090.ENSMUSP00000107238

UniGene: Mm.255165