Recombinant Mouse Interleukin-28A (Il28a)

中文名稱：

小鼠Ifnl2重組蛋白
貨號：

CSB-YP703302MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Ifnl2重組蛋白
貨號：

CSB-EP703302MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Ifnl2重組蛋白
貨號：

CSB-EP703302MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Ifnl2重組蛋白
貨號：

CSB-BP703302MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Ifnl2重組蛋白
貨號：

CSB-MP703302MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ifnl2
Uniprot No.：

Q4VK74
別名：

Ifnl2; Il28aInterferon lambda-2; IFN-lambda-2; Interleukin-28A; IL-28A
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

20-193
氨基酸序列

D PVPRATRLPV EAKDCHIAQF KSLSPKELQA FKKAKDAIEK RLLEKDLRCS SHLFPRAWDL KQLQVQERPK ALQAEVALTL KVWENMTDSA LATILGQPLH TLSHIHSQLQ TCTQLQATAE PRSPSRRLSR WLHRLQEAQS KETPGCLEAS VTSNLFRLLT RDLKCVANGD QCV
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
基因功能參考文獻：
1. Fetuses lacking IFN-lambda signaling had increased Zika virus replication in the placenta, and treatment of pregnant mice with IFN-lambda2 reduced ZIKV infection. PMID: 28910635
2. IFN-lambda2 and its receptor may become targets of anti-cancer therapy. PMID: 29151074
3. IL28 controls proliferation of IECs in mice with colitis and accelerates mucosal healing by activating STAT1. PMID: 28342759
4. IL-28A is capable of exacerbating a T-cell-mediated autoimmune disease. PMID: 25138017
5. Data indicate that rotavirus infection induces production of interferon-lambda (IFN-lambda) and interleukin 22 (IL-22) by intestinal epithelial cells. PMID: 26006013
6. IL-28A exerts its antiinflammatory effect by restricting recruitment of IL-1b-expressing neutrophils PMID: 25941255
7. The level of IFN-lambda2 was significantly increased in the infected cells treated with with shRNAs against influenza a virus M1. PMID: 26104331
8. IFN-lambda2 limits VSV replication in the mouse lung. PMID: 25008938
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亞細胞定位：

Secreted.
蛋白家族：

Lambda interferon family
數據庫鏈接：

KEGG: mmu:330496

STRING: 10090.ENSMUSP00000080384

UniGene: Mm.454510