E. coli biotin ligase
(BirA) is highly specific in covalently attaching biotin to the 15
amino
acid AviTag peptide. This recombinant protein was biotinylated in
vivo
by AviTag-BirA technology, which method is BriA catalyzes amide
linkage
between the biotin and the specific lysine of the AviTag.
The tag type will
be
determined during production process. If you have specified tag
type, please tell us and we will develop the specified tag
preferentially.
產品提供形式:
Lyophilized
powder
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Note: We will
preferentially ship the format that we have in stock, however,
if you have any special requirement for the format, please
remark your requirement when placing the order, we will prepare
according to your demand.
復溶:
We recommend that this vial be briefly centrifuged
prior
to opening to bring the contents to the bottom. Please reconstitute
protein in deionized sterile water to a concentration of 0.1-1.0
mg/mL.We recommend to add 5-50% of glycerol (final concentration)
and
aliquot for long-term storage at -20℃/-80℃. Our default final
concentration of glycerol is 50%. Customers could use it as
reference.
儲存條件:
Store at -20°C/-80°C upon receipt, aliquoting is
necessary for
mutiple use. Avoid repeated freeze-thaw cycles.
保質期:
The shelf life is related to many factors, storage
state,
buffer ingredients, storage temperature and the stability of the
protein
itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C.
The
shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期:
Delivery time may
differ from different purchasing way or location, please kindly
consult your local distributors for specific delivery time.
Note: All of our
proteins are default shipped with normal blue ice packs, if you
request to ship with dry ice, please communicate with us in
advance
and extra fees will be charged.
注意事項:
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Binds as a monomer with high affinity to interleukin-13 (IL13).
基因功能參考文獻:
Upon lipopolysaccharide stimulation, macrophage Raw 264.7 cells showed elevated IL-13R-alpha-2 expression via immunofluorescence staining and increased MRI probe binding via built-in TAMRA fluorescence imaging. for the first time, IL-13R-alpha-2 was investigated as a unique biomarker in the context of osteomyelitis. PMID: 28061526
Study presents evidence that PNR could promote ERalpha-negative breast cancer metastasis through activation of IL-13Ralpha2-mediated signaling pathway. PMID: 24747967
overexpression of IL-13Ra2 inhibits the IL-13 induction of fibrotic markers in vitro and inhibits bleomycin-induced pulmonary fibrosis. PMID: 25659898
data collectively support a distinct role for membrane IL-13Ralpha2 in the lung and suggest that memIL-13Ralpha2 might contribute to allergic inflammation PMID: 23763980
When combined with IL-13Ralpha2 DNA cancer vaccine, Pseudomonas aeruginosa exotoxin A mediates synergistic antitumor effects on tumor growth and metastasis in established murine breast carcinoma and sarcoma tumor models. PMID: 22013118
IL-13Ralpha2 serves a protective role in the pathogenesis of allergic inflammation and loss of skin barrier function in a mouse model of atopic dermatitis. PMID: 20971924
studies illustrate the central role played by the IL-13Ralpha2 in the down-regulation of a chronic and pathogenic Th2-mediated immune response PMID: 12642601
by suppressing IFN-gamma and up-regulating the decoy IL-13 receptor, P-selectin dramatically inhibits the pathologic tissue remodeling that results from chronic type 2 cytokine-mediated hepatic inflammation PMID: 14999686
IL-13Ralpha2 is a selective and powerful inhibitor of IL-13-induced inflammatory, remodeling, and physiologic responses in the murine lung. PMID: 18097054
Restoration of tumor immunosurveillance via targeting of interleukin-13 receptor-alpha 2. PMID: 18451175
study concludes that matrix metalloproteinase-8 cleaves IL-13R alpha 2 in vitro and contributes to the solubilization of IL-13R alpha 2 in vivo PMID: 18694590
Human and murine neuroendocrine pheochromocytoma overexpress the IL-13Ralpha2 chain, and an IL-13PE-based receptor-directed anticancer approach may prove useful in treatment for metastatic pheochromocytoma patients. PMID: 19491224
IL-13Ralpha2 plays an important role in nematode infection by limiting the availability of IL-13 during infection, thereby regulating both the immune and biological effects of IL-13. PMID: 19587021
IL-13Ralpha2 in macrophages may be a critical contributor to pathogenesis of schistosomiasis. PMID: 19719966
Humans only express the membrane bound form of the IL-13 receptor alpha 2 PMID: 18307523
The IL-13 receptor alpha 2 can be used to inhibit type-2 cytokine-mediated inflammation in the lung. PMID: 9916716
A soluble form of the IL-13 receptor alpha 2 inhibited IL-13 activity and the progression of liver fibrosis in schistosomiasis. PMID: 10491413
The IL-13 receptor alpha 2 suppresses granuloma formation, liver fibrosis, and portal hypertension in schistosomiasis and acts as a life-sustaining off signal for chronic and pernicious inflammation. PMID: 14699044
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亞細胞定位:
[Isoform 1]: Membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.