Recombinant Mouse Homer protein homolog 3 (Homer3)

中文名稱：

小鼠Homer3重組蛋白
貨號：

CSB-YP860797MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Homer3重組蛋白
貨號：

CSB-EP860797MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Homer3重組蛋白
貨號：

CSB-EP860797MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Homer3重組蛋白
貨號：

CSB-BP860797MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Homer3重組蛋白
貨號：

CSB-MP860797MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Homer3
Uniprot No.：

Q99JP6
別名：

Homer3; Homer protein homolog 3; Homer-3
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區(qū)域：

1-356
氨基酸序列

MSTAREQPIF STRAHVFQID PTTKRNWIPA GKHALTVSYF YDATRNVYRI ISIGGAKAII NSTVTPNMTF TKTSQKFGQW ADSRANTVYG LGFASEQQLT QFAEKFQEVK EAARLAREKS QDGGEFTSTG LALASHQVPP SPLVSTNGPG EEKLFRSQSA DTPGPTERER LKKMLSEGSV GEVQWEAEFF ALQDSNQRLA GALREANAAA TQWRQQLEVQ RAEAELLRQR VAELEAQVAV EPVRAGEKEA TSQSVEQLEA RVQTKDQTLK NQSTGTREAP DTAEREETQQ QVQDLETRNA ELEQQLRSME CNLEEARAER ERARAEVGRA AQLLDVRLFE LSELREGLAR LAEAAP
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.
基因功能參考文獻：
1. impaired mTORC1-Homer-3 activity underlies PC susceptibility in Spinocerebellar ataxia type 1 and presents a promising therapeutic target PMID: 26748090
2. Expression of Homer 3a/b is restricted to the developing cerebellum, hippocampus, and neonatal olfactory bulb, and is concentrated in the dendritic spines of Purkinje cells and their axons. PMID: 15116392
3. Homer3 in Purkinje cells might function as a reversible coupler regulated by CaMKII phosphorylation and that the phosphorylation is capable of regulating the postsynaptic molecular architecture in response to synaptic activity. PMID: 18480293
亞細胞定位：

Cytoplasm. Cell junction, synapse, postsynaptic density. Cell junction, synapse.
蛋白家族：

Homer family
組織特異性：

Expressed in the cerebellum, hippocampus, lung and thymus.
數(shù)據(jù)庫鏈接：

KEGG: mmu:26558

STRING: 10090.ENSMUSP00000003669

UniGene: Mm.388127