Recombinant Mouse Homeobox protein notochord (Noto)

中文名稱：

小鼠Noto重組蛋白
貨號：

CSB-YP722584MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Noto重組蛋白
貨號：

CSB-EP722584MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Noto重組蛋白
貨號：

CSB-EP722584MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Noto重組蛋白
貨號：

CSB-BP722584MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Noto重組蛋白
貨號：

CSB-MP722584MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Noto
Uniprot No.：

Q5TIS6
別名：

Noto; NotHomeobox protein notochord
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-240
氨基酸序列

MSSPAPSGTQ VQPGSLRPCP GAVSPVVPRR LARGRLESSF SVEAILARPK TRELAATSLP LSTCTSLNLL GAVSQYGVLP WVCSTGSWLP AYLSVGVYPL CSMSCVPGLN VTHHQQGLRL TGSELPYCLG PLKWAPTVDL RDHGTERHTK RVRTTFNLQQ LQELEKVFAK QHNLVGKERA QLAARLHLTE NQVRIWFQNR RVKYQKQQKL KLPSSSVMEE PSSSSDGNIQ SEDAELGIGS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcription factor that controls node morphogenesis. Acts downstream of both FOXA2 and Brachyury (T) during notochord development. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate. Activates the transcription of ciliary proteins C11orf97 homolog, FAM183B and SPACA9 in the embryonic ventral node.
基因功能參考文獻：
1. A novel mammal-specific three partite enhancer element regulates node and notochord-specific Noto expression. PMID: 23110100
2. noto and foxj1 have roles in node formation, nodal ciliogenesis and cilia positioning PMID: 22357932
3. findings suggest that Noto is involved in both rearrangement and morphogenesis of the tail bud during notochord formation. PMID: 20197654
4. Noto ss an essential regulator of node morphogenesis and ciliogenesis in the posterior notochord. PMID: 17884984
5. Lack of Noto correlates with misplacing and wrong directed differentiation of the tissue in the tail bud region PMID: 15550757
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相關疾病：

Defects in Noto are the cause of the truncate (tc) phenotype. Truncate (tc) is a recessive mutation that affects the development of the caudal notochord. Mice homozygous for tc are viable but viability is reduced, which is attributed at least in part to spinal injury in the sacral and lower lumbar region.
亞細胞定位：

Nucleus.
數據庫鏈接：

KEGG: mmu:384452

STRING: 10090.ENSMUSP00000087006

UniGene: Mm.347883