1. CM-695, a small molecule that induces the expression of the HSPA1A/B genes, increases the vessel wall levels of Hsp70 and prevents thrombosis at least as efficiently as rivaroxaban without increasing bleeding risk. PMID: 28837204
2. HSPA1A and HSPA8 have roles in parturition through stimulating immune inflammatory and estrogen response PMID: 28025138
3. HSPA1A/B induction is a novel approach to delay thrombus formation with minimal bleeding risk in knockout mice. PMID: 26976620
4. HspA1A-phosphoinositide binding is complex yet specific, is mediated by both electrostatic and hydrophobic interactions, is not related to the lipid-head charge, and depends on the physicochemical properties of the lipid. PMID: 26923070
5. The protective mechanism of HAS2 involves an increased expression of the heat-shock protein Hsp72, a chaperone with antiapoptotic activity PMID: 25555205
6. HspA1A embeds in membranes when bound to liposomes composed of cardiolipin and sulfatide.The two domains of HspA1A differentially bind to lipids, such as cardiolipin and sulfatide. PMID: 26476215
7. Knockdown lines were created for specific DSBs in regions of the chromosome that are coding for HSPA1A. Clonogenic cell survival was significantly lower in irradiated Hsp70 KD cells with low mHsp70 expression, than in ctrl cells. PMID: 26197988
8. genetic manipulation of Hsp72 does not lead to alterations in metabolic processes in cardiac tissue under resting conditions, but identifies mouse strain-specific differences in cardiac lipid accumulation and insulin-stimulated glucose clearance. PMID: 25618331
9. Data indicate that heat shock protein 70 (Hsp70) is higher in nuclear protein 1 (Nupr1+/-) haplodeficient mice, concomitant with improved insulin sensitivity. PMID: 25638293
10. HuR does not play a role in APA of the Hsp70.3 mRNA, and these two regulatory events appear to be mutually exclusive regulators of Hsp70.3 expression PMID: 25727182
11. Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance. PMID: 24430435
12. Activation of HSP-72 upregulates lung injury associated with Pseudomonas aeruginosa pneumonia. PMID: 24667831
13. In HSP72 knockout mice, impaired Parkin action was associated with retention of enlarged, dysmorphic mitochondria and paralleled by reduced muscle respiratory capacity, lipid accumulation, and muscle insulin resistance. PMID: 24379352
14. Pleural mesothelial cells can release Hsp72 in response to bacterial infection. PMID: 23704948
15. In heat stress conditions, Hsp73 is mobilized to prevent apoptosis in the testes and epididymis, and assists Hsp72 in the repair of stress-altered protein conformations. PMID: 23352621
16. Hsp72 had greater affinity for tau than Hsc70, but Hsc70 was 30 times more abundant than Hsp72 in human and mouse brain tissue. PMID: 23271055
17. Toll-like receptor agonists and febrile range hyperthermia synergize to induce heat shock protein 70 expression and extracellular release PMID: 23212905
18. Hsp72 overexpression accelerates the recovery from acute pancreatitis and may represent a potential treatment strategy. PMID: 22792201
19. These data indicate that early modulation of astrocyte activation provides an additional novel mechanism associated with Hsp72 overexpression in the setting of ischemia. PMID: 22940431
20. alternative polyadenylation of Hsp70.3 in parallel with ischemic or heat shock-induced up-regulation of mRNA levels and implicate the importance of this process in post-transcriptional control of Hsp70.3 expression. PMID: 21757701
21. Hsp72 has an essential role in Her2-induced tumorigenesis by regulating oncogene-induced senescence pathways PMID: 21297664
22. Upregulation of heat shock protein 72 by geldanamycin reduces brain injury in intracerebral hemorrhage. PMID: 20849898
23. Hsp72 reduced infarct area lost and improved behavioral outcome following transient focal cerebralischemia PMID: 21108992
24. C-terminus Hsp72 induced tolerance to subsequent LPS stimulation, whereas N-terminus Hsp72 did not induce tolerance PMID: 21094186
25. stress-induced GlcNAcylation increases HSF1 expression through inhibition of GSK-3beta, but decreases HSP72 PMID: 20926391
26. The results of infarct studies confirm that Hsp70.3 is protective after ischemic preconditioning. PMID: 20643136
27. confirmed that radiation therapy induces Hsp72 release primarily from implanted tumors PMID: 20430459
28. enhancing astrocyte resistance to ischemic stress by overexpressing either the cytosolic protein Hsp72 or the mitochondrial protein SOD2 resulted in improved survival of CA1 neurons following forebrain ischemia PMID: 20235222
29. BAG3 alters the interaction between HSP70 and IKKgamma, increasing availability of IKKgamma and protecting it from proteasome-dependent degradation; this, in turn, results in increased NF-kappaB activity and survival PMID: 20368414
30. inducible HSP70.1 and HSP70.3 are required for late-phase protection against myocardial infarction following ischemia preconditioning in mice. PMID: 12714332
31. The increased HSP72 expression of S(selection) mice is not a simple proximate effect of their increased wheel running. S mice had significantly elevated HSP72 expression only when housed with free wheels. PMID: 14672969
32. Exposure to ionizing radiation led to more residual chromosome aberrations, radioresistant DNA synthesis (a hallmark of genomic instability), increased cell killing, and enhanced IR-induced oncogenic transformation in Hsp70.1/3(-/-) cells. PMID: 14701760
33. rapidly induced by Staphylococcus aureus enterotoxin b in intestinal epithelial cells, both directly and through lymphocyte activation (Hsp72) PMID: 15155620
34. Hsp72 inhibits apoptosis upstream of the mitochondria and not through interactions with Apaf-1 PMID: 15371421
35. helix C is involved in the self-association of Hsp72. PMID: 15498567
36. These findings indicate that expression of hsp72 in the hippocampus varies as a function of the learning performance independently from exposure to chronic acoustic stress. PMID: 15719414
37. Hsp70 from hsp70.3 may be an initial retinal chaperone while hsp70 from hsp70.1 may be a sustained chaperone. PMID: 15988927
38. These results support a multifactoral protective effect of HSP72, some aspects dependent on nuclear localization with stress and some not. PMID: 16100242
39. Data show that conditioned media from Lactobacillus GG induce expression of heat shock protein (Hsp)25 and 72 in intestinal epithelial cells. PMID: 16306130
40. neuroprotective effects of Hsp70 overexpression in neonatal hypoxic/ischemic injury are mediated by apoptotic pathways through upregulation of FLIP and sequestering Apaf-1, leading to reduced cleavage of caspase-8 and caspase-9 PMID: 16397188
41. We report that preconditioning increased HSP72 and heme-oxygenase-1 (HO-1) at 6 and 24 hours of reperfusion, respectively. Unlike nonsteatotic livers, steatotic livers benefited from HSP72 activators (geranylgeranylacetone) throughout reperfusion. PMID: 16651615
42. eHsp72 was present in plasma and pulmonary edema (PE)fluid of ALI patients and it was significantly higher in PE fluid from patients with preserved alveolar epithelial fluid clearance. eHsp72 may serve as a marker of SPR activation of ALI patients. PMID: 16679378
43. Deletion of Hsp70 genes might induce cardiac dysfunction and development of cardiac hypertrophy through the activation of JNK, p38-MAPK, Raf-1, and ERK. PMID: 16735677
44. results indicate that hsp72 levels can serve as a host determinant of viral neurovirulence in C57BL/6 mice, reflecting the direct influence of hsp72 on viral gene expression PMID: 16971451
45. These competitive experiments imply that there may be at least two membrane receptors on P388D1 cells and also that both receptors may recognize the various structures in the C-terminal region of the Hsp70 family for regulation of innate immunity. PMID: 17126904
46. Heat-stress further enhanced the GGA-related up-regulation of HSP72. PMID: 17482577
47. Results suggest an important role for KLF4 as a novel regulator of the constitutive expression of HSP73, but not HSP72. PMID: 18379898
48. the absence of interleukin-6 is associated with reduced skeletal muscle Hsp72 PMID: 18927263
49. These results suggest that Hspa1a and Hspa1b play an important role in protecting embryos from hyperthermia-induced congenital defects. PMID: 19639652

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KEGG: mmu:193740

STRING: 10090.ENSMUSP00000084586

UniGene: Mm.6388