Recombinant Mouse Hairy and enhancer of split-related protein HELT (Helt)

中文名稱：

小鼠Helt重組蛋白
貨號：

CSB-YP766516MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Helt重組蛋白
貨號：

CSB-EP766516MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Helt重組蛋白
貨號：

CSB-EP766516MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Helt重組蛋白
貨號：

CSB-BP766516MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Helt重組蛋白
貨號：

CSB-MP766516MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Helt
Uniprot No.：

Q7TS99
別名：

Helt; Hesl; Mgn; Hairy and enhancer of split-related protein HELT; HES/HEY-like transcription factor; Protein Hes-like; Protein megane
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-240
氨基酸序列

MSDRLKERKR TPVSHKVIEK RRRDRINRCL NELGKTVPMA LAKQSSGKLE KAEILEMTVQ YLRALHSADF PRGREKELLA EFANYFHYGY HECMKNLVHY LTTVERMETK DTKYARILAF LQSKARLGAE PTFPPLSLPE PDFSYQLHAA SPEFPGHSPG EATMFPQGAT PGSFPWPPGA ARSPALPYLS SATVPLPSPA QQHSPFLAPM QGLDRHYLNL IGHGHPNGLN LHTPQHPPVL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'. Required for the development of GABAergic neurons.
基因功能參考文獻：
1. the combination of gain- and loss-of-function experiments in the developing midbrain showed co-operative roles for Mgn and Mash1 genes in determining GABAergic identity. PMID: 25993409
2. the prethalamic factors Dlxs upregulated by Ascl1/Helt deficiency play unique roles in regulating thalamic progenitor specification. PMID: 25512300
3. Helt acts as a transcriptional repressor to regulate neuronal differentiation and/or identity PMID: 14764602
4. identification of a novel mouse bHLH factor, termed Heslike, that has Hes1-like bHLH domain and transcriptional repressor activity; Heslike is coexpressed with the bHLH factor Mash1 in brain regions that give rise to GABAergic neurons PMID: 15071116
5. Mgn is a single copy gene on mouse chromosome 8 and encodes a 27kDa protein that functions in the nucleus. PMID: 16644143
6. Homozygous Mgn-null mice die between the second and the fifth postnatal week of age, and show a complete depletion of Gad65 and Gad67 expression in the superior colliculus and a reduction in the inferior colliculus. PMID: 16968817
7. Helt determines GABAergic over glutamatergic fate, by repressing Ngn genes; Helt and Ngns are commonly used in the mesencephalon for determination of the GABAergic versus glutamatergic transmitter phenotype. PMID: 17611227
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亞細胞定位：

Nucleus.
蛋白家族：

HEY family
組織特異性：

Expressed in heart and testis.
數據庫鏈接：

KEGG: mmu:234219

STRING: 10090.ENSMUSP00000054823

UniGene: Mm.145631