Recombinant Mouse H (+)/Cl (-) exchange transporter 5 (Clcn5), partial

中文名稱：

Recombinant Mouse H(+)/Cl(-) exchange transporter 5(Clcn5),partial
貨號(hào)：

CSB-YP893433MO
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

Recombinant Mouse H(+)/Cl(-) exchange transporter 5(Clcn5),partial
貨號(hào)：

CSB-EP893433MO
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

Recombinant Mouse H(+)/Cl(-) exchange transporter 5(Clcn5),partial
貨號(hào)：

CSB-EP893433MO-B
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse H(+)/Cl(-) exchange transporter 5(Clcn5),partial
貨號(hào)：

CSB-BP893433MO
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse H(+)/Cl(-) exchange transporter 5(Clcn5),partial
貨號(hào)：

CSB-MP893433MO
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Clcn5
Uniprot No.：

Q9WVD4
別名：

Clcn5; Clc5H(+)/Cl(-) exchange transporter 5; Chloride channel protein 5; ClC-5; Chloride transporter ClC-5
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function.
基因功能參考文獻(xiàn)：
1. This study demonistrated that Clcn5 gene expression in mouse dorsal raphe nucleus PMID: 22534482
2. ClC-5 plays an essential role in exocytosis of NHE3. PMID: 21561868
3. HNF1alpha directly regulates the expression of ClC-5 in the renal proximal tubule PMID: 20810608
4. ClC-5 is unique among CLC proteins in being crucial for proximal tubular endocytosis and the PY-motif-dependent ubiquitylation of ClC-5 is dispensable for this rol PMID: 20351103
5. findings show that endosomal chloride concentration, which is raised by ClC-5 in exchange for protons accumulated by H+-ATPase, may play a role in endocytosis PMID: 20430975
6. Our studies demonstrate a role for CLC-5 in the immunopathogenesis of ulcerative colitis PMID: 20181886
7. ClC-5 regulates dentin development through TGF-beta1 pathway PMID: 19878925
8. Disruption of CLC-5 expression causes abnormal calcium crystal agglomeration on the surface of kidney collecting duct cells. PMID: 12504084
9. hypercalciuria in the ClC-5 KO mice on low and high calcium diets is of bone and renal origin and is not caused by increased intestinal calcium absorption PMID: 12674322
10. Impaired protein endocytosis caused by invalidation of ClC-5 primarily reflects a trafficking defect of megalin and cubilin in PTC. PMID: 12815097
11. A role for CBS domain 2 in transport of CLC-5. PMID: 14521953
12. The segmental expression of ClC-5 and H+-ATPase is essentially achieved during early nephrogenesis, in parallel with the onset of glomerular filtration. PMID: 14675051
13. collecting duct cells with reduced CLC-5 expression lead to a tendency to form calcium crystal agglomeration PMID: 15158917
14. increased CLC-5 levels in mouse medullary thick ascending limb may serve to maintain the endocytotic activity in a hypertonic environment. PMID: 15161605
15. Our results provide direct evidence for ClC-5 involvement in acidification of early endosomes in proximal tubule by a chloride shunt mechanism. PMID: 15752747
16. High citrate diet preserved renal function and delayed progression of renal disease in ClC-5 knockout mice even in the apparent absence of stone formation. PMID: 16014041
17. ClC-5 has a role in apical iodide efflux and in euthyroid goiter in the mouse thyroid gland PMID: 16306076
18. Target genes of 1,25(OH)(2)-vitamin D(3) were upregulated in ClC-5 knockout kidneys. PMID: 16672909
19. in the thyroid, unlike in the kidney, ClC-5 does not affect megalin expression and function PMID: 16910872
20. observed a significant decrease in solute carrier family 2 protein expression levels in isolated proximal tubule ((n=10, p<0.01)) of knockout mice PMID: 17762172
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亞細(xì)胞定位：

Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
蛋白家族：

Chloride channel (TC 2.A.49) family, ClC-5/CLCN5 subfamily
組織特異性：

Kidney specific.
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:12728

STRING: 10090.ENSMUSP00000111412

UniGene: Mm.486257