Recombinant Mouse Guanylate cyclase soluble subunit alpha-3 (Gucy1a3)

中文名稱：

小鼠Gucy1a1重組蛋白
貨號：

CSB-YP861695MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Gucy1a1重組蛋白
貨號：

CSB-EP861695MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Gucy1a1重組蛋白
貨號：

CSB-EP861695MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Gucy1a1重組蛋白
貨號：

CSB-BP861695MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Gucy1a1重組蛋白
貨號：

CSB-MP861695MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Gucy1a1
Uniprot No.：

Q9ERL9
別名：

Gucy1a1; Gucy1a3Guanylate cyclase soluble subunit alpha-1; GCS-alpha-1; EC 4.6.1.2; Guanylate cyclase soluble subunit alpha-3; GCS-alpha-3; Soluble guanylate cyclase large subunit
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-691
氨基酸序列

MFCRKFKDLK ITGECPFSLL APGQVPKEPT EEVAGGSEGC QATLPICQYF PEKNAEGSLP QRKTSRNRVY LHTLAESICK LIFPECERLN LALQRTLAKH KIEENRKSSE KEDLEKIIAE EAIAAGAPVE ALKDSLGEEL FKICYEEDEH ILGVVGGTLK DFLNSFSTLL KQSSHCQEAE RRGRLEDASI LCLDKDQDFL NVYYFFPKRT TALLLPGIIK AAARILYESH VEVSLMPPCF RSDCTEFVNQ PYLLYSVHVK STKPSLSPGK PQSSLVIPAS LFCKTFPFHF MLDRDLAILQ LGNGIRRLVN KRDFQGKPNF EEFFEILTPK INQTFSGIMT MLNMQFVIRV RRWDNSVKKS SRVMDLKGQM IYIVESSAIL FLGSPCVDRL EDFTGRGLYL SDIPIHNALR DVVLIGEQAR AQDGLKKRLG KLKATLEHAH QALEEEKKRT VDLLCSIFPS EVAQQLWQGQ IVQAKKFSEV TMLFSDIVGF TAICSQCSPL QVITMLNALY TRFDQQCGEL DVYKVETIGD AYCVAGGLHR ESDTHAVQIA LMALKMMELS NEVMSPHGEP IKMRIGLHSG SVFAGVVGVK MPRYCLFGNN VTLANKFESC SVPRKINVSP TTYRLLKDCP GFVFTPRSRE ELPPNFPSDI PGICHFLDAY HHQGPNSKPW FQDKDVEDGN ANFLGKASGI D
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

基因功能參考文獻：
1. Exogenous or paracrine sources of NO promote the specification towards the myocyte lineage and expression of cardiac sarcomeric proteins of adult cardiac progenitor cells. This is contingent upon the expression and activity of the alpha1 subunit of guanylyl cyclase in CPC that is necessary for NO-mediated inhibition of the canonical Wnt/beta-catenin pathway. PMID: 27520736
2. These data demonstrate that a reduction in cardiac sGC activity worsens doxorubicin-induced cardiotoxicity in mice and identify sGC as a potential therapeutic target. PMID: 27505125
3. We suggest that Gucy1a3 activity promotes the phenotypic switching of smooth muscle cells from a contractile to a synthetic state, fostering the formation of atherosclerosis. PMID: 27315776
4. The authors elucidated this dependency by showing that guanylate cyclase-1 is a novel rhodopsin-binding protein. PMID: 26590321
5. Cellular markers revealed that vascular SMC differentiation decreased, whereas myofibroblast activation increased in the hyperoxic sGC-alpha1 KO pup lung. PMID: 23934926
6. Soluble guanylate cyclase alpha1-deficient mice: a novel murine model for primary open angle glaucoma. PMID: 23527308
7. Male mice deficient in a NO receptor component, the alpha1 subunit of soluble guanylate cyclase (sGCalpha1), are prone to hypertension in some, but not all, mouse strains, suggesting that additional genetic factors contribute to the onset of hypertension PMID: 22565307
8. results show that the loss of sGCalpha1 has a positive inotropic and lusitropic effect on basal cardiac function, indicating an important role for sGCalpha1 in regulating basal myocardial contractility PMID: 21394564
9. RD3 mediates the export of GC1 from the endoplasmic reticulum to endosomal vesicles, and that the C terminus of GC1 is required for RD3 binding PMID: 21078983
10. Requirement of both alpha-2 and alpha-1 guanylate cyclases for signaling in long-term potentiation (LTP) indicates the existence of two distinct nitric oxide/cGMP-mediated pathways, which have to work in concert for expression of LTP. PMID: 17251421
11. sGCalpha1 is essential for NO-mediated pulmonary vasodilation and limits chronic hypoxia-induced pulmonary vascular remodeling PMID: 17679618
12. guanylate cyclase has a role in pulmonary arterial hypertension PMID: 18550612
13. NFATc3 and HuR are important regulators of sGC-alpha1 expression in pulmonary vascular smooth muscle cells during chronic hypoxia-induced pulmonary hypertension. PMID: 19592461
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亞細胞定位：

Cytoplasm.
蛋白家族：

Adenylyl cyclase class-4/guanylyl cyclase family
數據庫鏈接：

KEGG: mmu:60596

STRING: 10090.ENSMUSP00000048918

UniGene: Mm.143831