Recombinant Mouse Growth factor receptor-bound protein 14 (Grb14)

中文名稱：

小鼠Grb14重組蛋白
貨號：

CSB-YP009888MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Grb14重組蛋白
貨號：

CSB-EP009888MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Grb14重組蛋白
貨號：

CSB-EP009888MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Grb14重組蛋白
貨號：

CSB-BP009888MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Grb14重組蛋白
貨號：

CSB-MP009888MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Grb14
Uniprot No.：

Q9JLM9
別名：

Grb14; Growth factor receptor-bound protein 14; GRB14 adapter protein
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達(dá)區(qū)域：

2-538
氨基酸序列

TTSLQDGQS AAGRAGAQDS PLAVQVCRVA QGKGDAQDPA QVPGLHALSP ASDATLRGAI DRRKMKDLDV LEKPPIPNPF PELCCSPLTS VLSAGLFPRA NSRKKQVIKV YSEDETSRAL EVPSDITARD VCQLLILKNH YVDDNSWTLF EHLSHIGLER TVEDHELPTE VLSHWGVEED NKLYLRKNYA KYEFFKNPMY FFPEHMVSFA AEMNGDRSPT QILQVFLSSS TYPEIHGFLH AKEQGKKSWK KAYFFLRRSG LYFSTKGTSK EPRHLQLFSE FSTSHVYMSL AGKKKHGAPT PYGFCLKPNK AGGPRDLKML CAEEEQSRTC WVTAIRLLKD GMQLYQNYMH PYQGRSACNS QSMSPMRSVS ENSLVAMDFS GEKSRVIDNP TEALSVAVEE GLAWRKKGCL RLGNHGSPSA PSQSSAVNMA LHRSQPWFHH RISRDEAQRL IIRQGPVDGV FLVRDSQSNP RTFVLSMSHG QKIKHYQIIP VEDDGELFHT LDDGHTKFTD LIQLVEFYQL NRGVLPCKLK HYCARMAV
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
基因功能參考文獻(xiàn)：
1. Study reveals that Grb14 acts as a new signaling node that regulates lipogenesis and modulates insulin sensitivity in the liver by acting at a crossroad between the insulin receptor and the p62-Nrf2-LXR signaling pathways. PMID: 27215388
2. The phosphorylation status of the BPS region of Grb14 determines the positive or negative role it will play in insulin receptor signaling. PMID: 24350791
3. Grb14 is a normal physiological modulator of CNG channel function in vivo. PMID: 20890309
4. Grb14 functions in vivo as a tissue-specific modulator of insulin action, most likely via repression of IR-mediated IRS-1 tyrosine phosphorylation PMID: 14749734
5. regulation of Grb14 expression in adipose tissue may play a physiological role in insulin sensitivity PMID: 15059968
6. Grb14 exerts a dual role on the regulation by insulin of hepatic metabolism. It inhibits insulin receptor catalytic activity, and as a sterol regulatory element binding protein-1c maturation. PMID: 18339716
7. These results demonstrate that Grb14 can undergo subcellular redistribution upon illumination and suggest that rhodopsin photoexcitation may trigger signaling events alternative to the classical transducin activation. PMID: 19438210
8. Grb10 and Grb14 have roles in regulation of insulin signaling and glucose homeostasis PMID: 19541746
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亞細(xì)胞定位：

Cytoplasm. Endosome membrane; Peripheral membrane protein.
蛋白家族：

GRB7/10/14 family
數(shù)據(jù)庫鏈接：

KEGG: mmu:50915

STRING: 10090.ENSMUSP00000028252

UniGene: Mm.214554