Recombinant Mouse Glutamine-rich protein 1 (Qrich1)

中文名稱：

小鼠Qrich1重組蛋白
貨號：

CSB-YP662334MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Qrich1重組蛋白
貨號：

CSB-EP662334MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Qrich1重組蛋白
貨號：

CSB-EP662334MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Qrich1重組蛋白
貨號：

CSB-BP662334MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Qrich1重組蛋白
貨號：

CSB-MP662334MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Qrich1
Uniprot No.：

Q3UA37
別名：

Qrich1; Glutamine-rich protein 1
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-777
氨基酸序列

MNNSLENTIS FEEYIRVKAR SVPQHRMKEF LDSLASKGPE ALQEFQQTAT TTMVYQQGGN CIYTDSTEVA GSLLELACPV TTSVQPQTQQ EQQIQVQQPQ QVQVQVQVQQ SPQQVSAQQL SPQFTVHQPA EQPIQVQVQI QGQAPQSAAP SIQTPSLQSP SPSQLQAAQI QVQHVQAAQQ IQAAEIPEEH IPHQQIQAQL VAGQSLAGGQ QIQIQTVGAL SPPPSQQGSP REGERRVGTA SVLQPVKKRK VDMPITVSYA ISGQPVATVL AIPQGQQQSY VSLRPDLLTV DSAHLYSATG TITSPTGETW TIPVYSAQPR GDPQQQSITH IAIPQEAYNA VHVSGSPKAL AAVKLEDDKE KMVGTTSVVK NSHEEVVQTL ANSLFPAQFM NGNIHIPVAV QAVAGTYQNT AQTVHIWDPQ QQPQQQTAQE QTPPPQQQQQ QLQVTCSAQT VQVAEVEPQS QPQPSPELLL PNSLKPEEGL EVWKNWAQTK NAELEKDAQN RLAPIGRRQL LRFQEDLISS AVAELNYGLC LMTREARNGE GEPYDPDVLY YIFLCIQKYL FENGRVDDIF SDLYYVRFTE WLHEVLKDVQ PRVTPLGYVL PSHVTEEMLW ECKQLGAHSP STLLTTLMFF NTKYFLLKTV DQHMKLAFSK VLRQTKKSPS NPKDKSTSIR YLKALGIHQT GQKVTDDMYA EQTENPENPL RCPIKLYDFY LFKCPQSVKG RNDTFYLTPE PVVAPNSPIW YSVQPISREQ MGQMLTRILV IREIQEAIAV ANATTMH
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress. Controls the outcome of the unfolded protein response (UPR), an ER-stress response pathway that either promotes recovery of ER homeostasis and cell survival, or triggers the terminal UPR which elicits programmed cell death when ER stress is prolonged and unresolved. ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR. May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability. Upregulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver. Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth.
亞細胞定位：

Nucleus. Cytoplasm. Cell membrane.
組織特異性：

Expressed highly in prefrontal cortex, craniofacial area and near the limbs of mouse embryos. Expressed in heart, skeletal muscle, liver, kidney, lung, brain, spleen, intestine and growth plate in mice.
數據庫鏈接：

KEGG: mmu:69232

STRING: 10090.ENSMUSP00000006851

UniGene: Mm.335449