Recombinant Mouse Gasdermin-A (Gsdma)

中文名稱：

小鼠Gsdma重組蛋白
貨號：

CSB-YP880660MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Gsdma重組蛋白
貨號：

CSB-EP880660MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Gsdma重組蛋白
貨號：

CSB-EP880660MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Gsdma重組蛋白
貨號：

CSB-BP880660MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Gsdma重組蛋白
貨號：

CSB-MP880660MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Gsdma
Uniprot No.：

Q9EST1
別名：

Gsdma; Gsdm; Gsdm1; Gsdma1Gasdermin-A; Gasdermin-1; Gasdermin-A1
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-446
氨基酸序列

MTMFENVTRA LARQLNPRGD LTPLDSLIDF KRFHPFCLVL RKRKSTLFWG ARYVHTDYTL LDVLEPGSSP SDPTDSGNFS FKNMLDARVE GDVDVPKTVK VKGTAGLSRS STLEVQTLSV APTALENLHK ERKLSADHPF LKEMRERGEN LYVVMEVVET LQEVTLERAG KAEGCFSLPF FAPLGLQGSV NHKEAVTIPK GCVLAYRVRQ LMVNGKDEWG IPHICNDSMQ TFPPGEKPGE GKFILIQASD VGEMHEDFKT LKEEVQRETQ EVEKLSPVGR SSLLTSLSHL LGKKKELQDL EQTLEGALDK GHEVTLEALP KDVLLSKDAM DAILYFLGAL TVLSEAQQKL LVKSLEKKIL PVQLKLVEST MEKNFLQDKE GVFPLQPDLL SSLGEEELIL TEALVGLSGL EVQRSGPQYT WDPDTLPHLC ALYAGLSLLQ LLSKNS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-A, N-terminal) binds to membranes and forms pores, triggering cell death.; Pore-forming protein that causes membrane permeabilization and pyroptosis. Released upon cleavage of Gasdermin-A, and binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis. Binds to membrane inner leaflet lipids, such as phosphatidylinositol (4,5)-bisphosphate. The functional mechanisms and physiological proteases that cleave and activate this pore-forming protein are unknown.
亞細胞定位：

[Gasdermin-A]: Cytoplasm, perinuclear region. Cytoplasm, cytosol.; [Gasdermin-A, N-terminal]: Cell membrane; Multi-pass membrane protein.
蛋白家族：

Gasdermin family
組織特異性：

Expressed predominantly in the gastrointestinal (GI) tract and in the skin at a lower level. In the GI tract, the expression is highly restricted to the esophagus and forestomach.
數據庫鏈接：

KEGG: mmu:57911

STRING: 10090.ENSMUSP00000017348

UniGene: Mm.458085