Recombinant Mouse Galactoside 2-alpha-L-fucosyltransferase 2 (Fut2), partial

中文名稱：

小鼠Fut2重組蛋白
貨號：

CSB-YP862405MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Fut2重組蛋白
貨號：

CSB-EP862405MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Fut2重組蛋白
貨號：

CSB-EP862405MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Fut2重組蛋白
貨號：

CSB-BP862405MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Fut2重組蛋白
貨號：

CSB-MP862405MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Fut2
Uniprot No.：

Q9JL27
別名：

Fut2; Sec2; Galactoside 2-alpha-L-fucosyltransferase 2; EC 2.4.1.344; EC 2.4.1.69; Alpha(1,2)FT 2; Fucosyltransferase 2; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2; Secretory blood group protein 2
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation. Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs. Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway.
基因功能參考文獻：
1. Results indicate that the fucosyltransferase 2 (FUT2) determines the O-glycosylation pattern of mucin-5AC (Muc5ac). PMID: 27161092
2. Fut2 gene expression is responsible for disease progression in mice with primary sclerosing cholangitis. PMID: 28056490
3. These data suggest a novel role for Fut2 as a regulator of angiogenesis. PMID: 23065099
4. Fucosyltransferase Fut)-deficient (Fut1, Fut2 and Fut4) mice which lack LeX or LeY antigen are still fertile. PMID: 20876654
5. These data demonstrate that epithelial Fut2 mRNA expression is regulated by factors including LIF and IL1B secreted from macrophages recruited during the inflammatory response to insemination. PMID: 20864644
6. open reading frame encoded 347 amino acids with a predicted molecular mass of 39.21 kDa and exhibited sequence homology with murine H & Sec1 gene[alpha1,2-fucosyltransferase ] PMID: 16416971
7. An impairment of BabA-dependent adhesion of H. pylori to Fut2-null mice gastric mucosa, whereas SabA-mediated binding was not affected. PMID: 19706747
8. FUT2-encoded enzyme preferentially participates in the fucosylation of GA1 and GM1 in gastrointestinal tissues. Female reproductive organs were similarly found to utilize FUT2 for the fucosylation of glycolipids FGA1 (uterus and cervix), & FGM1 (ovary). PMID: 14967068
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亞細胞定位：

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
蛋白家族：

Glycosyltransferase 11 family
組織特異性：

Expressed in stomach, colon, ovary and uterus, specifically in luminal uterine epithelium. Expressed in various tissues including heart, liver, kidney, testis, epididymis, small intestine,and cecum. Expressed in duodenum, jejunum and ileum.
數據庫鏈接：

KEGG: mmu:14344

STRING: 10090.ENSMUSP00000063719

UniGene: Mm.290046