Recombinant Mouse GRB2-associated-binding protein 1 (Gab1)

中文名稱：

小鼠Gab1重組蛋白
貨號：

CSB-YP882572MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Gab1重組蛋白
貨號：

CSB-EP882572MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Gab1重組蛋白
貨號：

CSB-EP882572MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Gab1重組蛋白
貨號：

CSB-BP882572MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Gab1重組蛋白
貨號：

CSB-MP882572MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Gab1
Uniprot No.：

Q9QYY0
別名：

Gab1; GRB2-associated-binding protein 1; GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-695
氨基酸序列

MSGGEVVCSG WLRKSPPEKK LKRYAWKRRW FVLRSGRLTG DPDVLEYYKN DHAKKPIRII DLNLCQQVDA GLTFNKKEFE NSYIFDINTI DRIFYLVADS EEDMNKWVRC ICDICGFNPT EEDPVKPLTG SSQAPVDSPF AISTAPASSQ MEASSVALPP PYQVISLPPH PDTLGLQDDP QDYLLLINCQ SKKPEPNRTL FDSAKPTFSE TDCNDNVPSH QTPASSQSKH GMNGFFQQQM MYDCPPSRLT SVSGESSLYN LPRSYSHDVL PKESPSSTEA DGELYTFNTP SGTAGVETQM RHVSISYDIP PTPGNTYQIP RTFPESTLGQ SSKLDTIPDI PPPRPPKPHP THDRSPVETC GVPRTASDTD SSYCIPPPAG MTPSRSNTIS TVDLNKLRKD ASSQDCYDIP RTFPSDRSSS LEGFHSQYKI KSVLTAGGVS GEELDENYVP MNPNSPPRQH SGSFTEPIQE PNYVPMTPGT FDFSSFGMQV PPPAHMGFRS SPKTPPRRPV PVADCEPPPV DRNLKPDRKV KPAPLDIKPL SEWEELQAPV RSPITRSFAR DSSRFPMSPR PDSVHSTTSS SDSHDSEENY VPMNPNLSGE DPNLFASNSL DGGSSPMNKP KGDKQVEYLD LDLDSGKSTP PRKQKSSGSG SSMADERVDY VVVDQQKTLA LKSTREAWTD GRQSTESETP TKNVK
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway.
基因功能參考文獻：
1. Conditional Gab1 knockout mice showed general retardation in muscular growth and hypotrophy of extrafusal muscle fibers. Muscle-specific Gab1 knockout mutant exhibited significant underdevelopment of muscle spindles, which are normally regulated by NRG1, and abnormal proprioceptive behavior. Selective knockdown of Gab1 in C2C12 muscle cells reduced NRG1-induced expression of Egr3. PMID: 28542067
2. Data, including data from studies in transgenic/knockout mice, suggest expression of Gab1/Gab2 is up-regulated in activated macrophages in pulmonary fibrosis; both Gab1/Gab2 are recruited to Il4r, synergistically enhancing downstream signal amplification. (Gab1 = growth factor receptor bound protein 2-associated protein 1; Gab2 = growth factor receptor bound protein 2-associated protein 2; Il4r = interleukin-4 receptor) PMID: 28687632
3. these findings suggest that the striated muscle-specific high-MW isoform of Gab1 has a crucial role for NRG-1/ErbB signaling in cardiomyocytes. PMID: 27861634
4. These findings provide the direct evidence about the roles of docking protein Gab1 in lungs. PMID: 27793798
5. These results demonstrate that cardiomyocyte Gab1 is a critical regulator of the compensatory cardiac response to aging and hemodynamic stress. PMID: 26517531
6. Gab1 is essential regulator of the hair cycle and the self-renewal of hair follicle stem cells. PMID: 26456821
7. Hepatocyte Gab1 is required for liver fibrosis and that hepatocyte CCL5 could be an important contributor to this process. PMID: 25617348
8. endothelial Gab1 signaling inhibited splenomegaly in portal hypertension independent of angiogenesis. PMID: 25501549
9. Suggest that Gab1 is essential for cardioprotection against ischemia reperfusion oxidative injury, mediating survival signaling. PMID: 24951957
10. These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development PMID: 24284065
11. endothelial Gab1 deletion accelerates AngII-dependent vascular inflammation and atherosclerosis on ApoE-null background presumably in association with downregulation of KLF2 and KLF4. PMID: 22664868
12. The scaffolding adaptor GAB1 interacts with two polarity proteins, PAR1 and PAR3. PMID: 22883624
13. Gab1 is essential for postnatal angiogenesis through mediating angiogenic and survival signaling. PMID: 21372298
14. PECAM-1-mediated inhibition of GPVI-dependent platelet responses result from recruitment of SHP-2-p85 complexes to tyrosine-phosphorylated PECAM-1, which diminishes the association of PI3K with activatory signaling molecules Gab1 and LAT PMID: 20723025
15. in myeloid cells, Gab1 is likely to enhance HGF mitogenicity by coupling Met to Shp-2 and GATA-2 expression, thereby potentially contributing to normal myeloid differentiation as well as oncogenic transformation PMID: 20506405
16. These data show that a Gab1-Nck signalling complex interacts with several receptor tyrosine kinases to promote polarised actin remodelling and downstream biological responses. PMID: 20332103
17. Gab1 is needed for full activation of TLR3/4- and RIG-I-triggered innate responses by promoting activation of PI3K/Akt, MAPKs, and NF-kappaB pathways PMID: 20435932
18. Results show that Gab1-mediated signals in osteoblasts are crucial for normal postnatal bone homeostasis. PMID: 20124419
19. comparative FISH mapping of Gab1 and Gab2 genes in human, mouse and rat PMID: 11701952
20. Gab1 is a unique negative regulator of the thymus-independent antigen-2 response specifically expressed in splenic marginal zone B cells. PMID: 11994464
21. distinct recruitment and function in Met receptor-mediated epithelial morphogenesis PMID: 12058075
22. Gab1 is an integrator of cell death versus cell survival signals in oxidative stress PMID: 12808090
23. Gab1-deficient mouse fibroblast cells were defective in induction of JNK activity by UV exposure or heat shock PMID: 14749370
24. Gab1 plays a selective role in the regulation of the mitogen-activated protein kinases Erk and p38 downstream of the PDGF beta-receptor, and contributes to cytoskeletal reorganization and chemotaxis in response to PDGF PMID: 14973141
25. coupling of Gab1 to PI3K is important for biological responses in RET-expressing cells PMID: 15351743
26. Gab1 acts to attenuate, through promotion of the Erk pathway, insulin-elicited signals flowing through IRS and Akt proteins, which represents a novel balancing mechanism for control of insulin signal strength in the liver. PMID: 15821749
27. Gab1 and Cxcr4 cooperate to control the development of migrating muscle stem cells. PMID: 16166380
28. shear stress-induced activation of eNOS depends on Gab1 and SHP2, which, in turn, regulate the phosphorylation and activity of eNOS by a PKA-dependent but Akt-independent mechanism. PMID: 16284184
29. physiological significance of the Gab1/Shp2 link in promoting mitogenic signaling through the Erk pathway in liver regeneration PMID: 16738330
30. This study provides the first evidence that Gab1 is a key binding partner of the Met receptor for induction of cell cycle progression, proliferation, and oncogenic morphological transformation. PMID: 16775003
31. These results underscore the non-redundant and essential roles of Gab1 and Gab2 in endothelial cells, and suggest major contributions of these proteins during in vivo angiogenesis. PMID: 19233262
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蛋白家族：

GAB family
組織特異性：

Expressed in the inner ear (at protein level). Expression is detected in the cochlear duct, spiral limbus region, efferent and afferent nerves, and in spiral ganglion neurons (at protein level).
數據庫鏈接：

KEGG: mmu:14388

STRING: 10090.ENSMUSP00000034150

UniGene: Mm.277409