Recombinant Mouse Ethanolamine-phosphate cytidylyltransferase (Pcyt2)

中文名稱：

小鼠Pcyt2重組蛋白
貨號：

CSB-YP856371MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Pcyt2重組蛋白
貨號：

CSB-EP856371MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Pcyt2重組蛋白
貨號：

CSB-EP856371MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Pcyt2重組蛋白
貨號：

CSB-BP856371MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Pcyt2重組蛋白
貨號：

CSB-MP856371MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Pcyt2
Uniprot No.：

Q922E4
別名：

Pcyt2; Ethanolamine-phosphate cytidylyltransferase; EC 2.7.7.14; CTP:phosphoethanolamine cytidylyltransferase; Phosphorylethanolamine transferase
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區(qū)域：

1-404
氨基酸序列

MIRNGHGAAS AAGLKGPGDQ RIVRVWCDGC YDMVHYGHSN QLRQARAMGD YLIVGVHTDE EIAKHKGPPV FTQEERYKMV QAIKWVDEVV PAAPYVTTLE TLDKHNCDFC VHGNDITLTV DGRDTYEEVK QAGRYRECKR TQGVSTTDLV GRMLLVTKAH HSSQEMSSEY REYADSFGKP PHPTPAGDTL SSEVSSQCPG GQSPWTGVSQ FLQTSQKIIQ FASGKEPQPG ETVIYVAGAF DLFHIGHVDF LQEVHKLAKR PYVIAGLHFD QEVNRYKGKN YPIMNLHERT LSVLACRYVS EVVIGAPYSV TAELLNHFKV DLVCHGKTEI VPDRDGSDPY QEPKRRGIFY QIDSGSDLTT DLIVQRIIKN RLEYEARNQK KEAKELAFLE ATKQQEAPPG GEID
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Ethanolamine-phosphate cytidylyltransferase that catalyzes the second step in the synthesis of phosphatidylethanolamine (PE) from ethanolamine via the CDP-ethanolamine pathway. Phosphatidylethanolamine is a dominant inner-leaflet phospholipid in cell membranes, where it plays a role in membrane function by structurally stabilizing membrane-anchored proteins, and participates in important cellular processes such as cell division, cell fusion, blood coagulation, and apoptosis.
基因功能參考文獻：
1. we conclude that NF-Y and YY1 are important for the basal transcription of Pcyt2 and that NF-Y is involved in the inhibitory effects of 25-HC on Pcyt2 transcription. PMID: 26310456
2. The data identify Pcyt2 and membrane Phosphatidylethanolamine biogenesis as important determinants of gender-specific differences in cardiac lipids and heart function. PMID: 25986609
3. The naturally occurring splice variant Pcyt2gamma has a function to restrain the enzyme activity through the formation of unproductive enzyme complexes. PMID: 24703999
4. differences in phosphorylation between Pcyt2 isoforms PMID: 24519946
5. hypertriglyceridemia that accompanies Pcyt2 deficiency is the result of multiple metabolic adaptations PMID: 22764088
6. data unambiguously establish that the TAG accumulation present in Pcyt2-deficient hepatocytes is a direct consequence of Pcyt2 gene deficiency and reduced functioning of the de novo Kennedy pathway PMID: 20427062
7. single Pcyt2 allele in heterozygotes can maintain phospholipid homeostasis PMID: 17325045
8. alternative splicing of the mPcyt2 transcript is ubiquitous but could also be regulated in a tissue-specific manner, producing a variable ratio of mPcyt2alpha/mPcyt2beta mRNAs PMID: 17646670
9. PE phospholipids, Pcyt2 deficiency generates compensatory changes in triglyceride and energy substrate metabolism, resulting in a progressive development of liver steatosis, hypertriglyceridemia, obesity, and insulin resistance PMID: 19625253
10. Regulation of the mouse CTP: phosphoethanolamine cytidylyltransferase gene Pcyt2 during myogenesis PMID: 19646513
11. study of the importance of the CDP-ethanolamine pathway in controlling the molecular species composition of phosphatidylethanolamine via Phosphoethanolamine cytidylyltransferase knock-out PMID: 19666474
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蛋白家族：

Cytidylyltransferase family
數(shù)據(jù)庫鏈接：

KEGG: mmu:68671

STRING: 10090.ENSMUSP00000026129

UniGene: Mm.21439