Recombinant Mouse Enteropeptidase (Tmprss15), partial

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中文名稱：

小鼠Tmprss15重組蛋白
貨號：

CSB-EP018824MO
說明書：

MSDS Datasheet
規(guī)格：

￥1836
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP018824MO could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Tmprss15.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP018824MO could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Tmprss15.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

Tmprss15
Uniprot No.：

P97435
別名：

Tmprss15; Entk; Prss7Enteropeptidase; EC 3.4.21.9; Enterokinase; Serine protease 7; Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain]
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
來源：

E.coli
分子量：

43.0kDa
表達區(qū)域：

830-1069aa
氨基酸序列

IVGGSDAQAGAWPWVVALYHRDRSTDRLLCGASLVSSDWLVSAAHCVYRRNLDPTRWTAVLGLHMQSNLTSPQVVRRVVDQIVINPHYDRRRKVNDIAMMHLEFKVNYTDYIQPICLPEENQIFIPGRTCSIAGWGYDKINAGSTVDVLKEADVPLISNEKCQQQLPEYNITESMICAGYEEGGIDSCQGDSGGPLMCQENNRWFLVGVTSFGVQCALPNHPGVYVRVSQFIEWIHSFLH
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-SUMO-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
產(chǎn)品描述：

The recombinant mouse Tmprss15 protein is a fusion protein consists of the mouse Tmprss15 protein (830-1069aa) partnered with the N-terminal 6xHis-SUMO tag. It was produced in the E.coli. This recombinant Tmprss15 protein's purity is greater than 90% determined by SDS-PAGE. After electrophoresis, there is a 44 kDa protein band presented on the gel.
TMPRSS15 have been previously implicated in neuronal function. Besides, novel compound heterozygous TMPRSS15 gene variants could cause enterokinase deficiency. Recently, TMPRSS15 shares high homology in the serine protease domains of TMPRSS2, thus, may participate in the cleavage of the S protein of SARS-CoV-2 during infection. Loss-of-function variants in the TMPRSS15 gene are responsible for EKD. The lack of enterokinase (EK) prevents the activation of trypsinogen, which leads to a disorder of intestinal protein absorption. To date, according to the Human Genome Mutation Database (HGMD), only four variants have been described in the TMPRSS15 gene. The TMPRSS15 gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which in turn activates other proenzymes, including chymotrypsinogen and procarboxypeptidases. Mutations in TMPRSS15 cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.
基因功能參考文獻：
1. Enteropeptidase could inhibit osteoclastogenesis in vitro through the cleavage of RANK. PMID: 23954298
2. peptide sequencing of amino terminus of light chain of cow enterokinase, identifying the cleavage site PMID: 1799406
亞細胞定位：

Membrane; Single-pass type II membrane protein.
蛋白家族：

Peptidase S1 family
數(shù)據(jù)庫鏈接：

KEGG: mmu:19146

STRING: 10090.ENSMUSP00000023566

UniGene: Mm.5184