Recombinant Mouse Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 (Enpp6)

中文名稱：

小鼠Enpp6重組蛋白
貨號：

CSB-YP804784MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Enpp6重組蛋白
貨號：

CSB-EP804784MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Enpp6重組蛋白
貨號：

CSB-EP804784MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Enpp6重組蛋白
貨號：

CSB-BP804784MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Enpp6重組蛋白
貨號：

CSB-MP804784MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Enpp6
Uniprot No.：

Q8BGN3
別名：

Enpp6; Glycerophosphocholine cholinephosphodiesterase ENPP6; GPC-Cpde; EC 3.1.4.-; EC 3.1.4.38; Choline-specific glycerophosphodiester phosphodiesterase; Ectonucleotide pyrophosphatase/phosphodiesterase family member 6; E-NPP 6; NPP-6
種屬：

Mus musculus (Mouse)
蛋白長度：

Extracellular domain
表達區(qū)域：

23-419
氨基酸序列

HRKLLVLL LDGFRSDYIS EDALASLPGF REIVNRGVKV DYLTPDFPSL SYPNYYTLMT GRHCEVHQMI GNYMWDPRTN KSFDIGVNRD SLMPLWWNGS EPLWITLMKA RRKVYMYYWP GCEVEILGVR PTYCLEYKTV PTDINFANAV SDALDSLKSG RADLAAIYHE RIDVEGHHYG PSSPQRKDAL RAVDTVLKYM IQWIQDRGLQ QDLNVILFSD HGMTDIFWMD KVIELSNYIS LDDLQQVKDR GPVVSLWPVP GKHSEIYHKL RTVEHMTVYE KESIPNRFYY KKGKFVSPLT LVADEGWFIA ESREMLPFWM NSTGKREGWQ RGWHGYDNEL MDMRGIFLAI GPDFKSNFRA APIRSVDVYN IMCHVAGITP LPNNGSWSRV VCMLKGQTS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids.
基因功能參考文獻：
1. The crystal structure of ENPP6 in complex with phosphocholine revealed that the choline moiety of the phosphocholine is recognized by a choline-binding pocket formed by conserved aromatic and acidic residues. The present study provides the molecular basis for ENPP6-mediated choline metabolism at atomic, cellular and tissue levels. PMID: 26888014
2. NPP6 has a specific role through the hydrolysis of polyunsaturated LPC, glycerophosphorylcholine, or sphingosylphosphorylcholine in kidney, brain and heart PMID: 15788404
亞細胞定位：

Cell membrane; Lipid-anchor, GPI-anchor.
蛋白家族：

Nucleotide pyrophosphatase/phosphodiesterase family
組織特異性：

Predominantly expressed in kidney with a lesser expression in brain and heart. In the brain and spinal cord, mainly expressed in the white matter. In oligodendrocytes, is predominantly detected in the myelin sheath. In the kidney, is predominantly express
數(shù)據(jù)庫鏈接：

KEGG: mmu:320981

STRING: 10090.ENSMUSP00000044608

UniGene: Mm.211429