Recombinant Mouse E3 ubiquitin-protein ligase Praja-2 (Pja2)

中文名稱：

小鼠Pja2重組蛋白
貨號：

CSB-YP772133MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Pja2重組蛋白
貨號：

CSB-EP772133MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Pja2重組蛋白
貨號：

CSB-EP772133MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Pja2重組蛋白
貨號：

CSB-BP772133MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Pja2重組蛋白
貨號：

CSB-MP772133MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Pja2
Uniprot No.：

Q80U04
別名：

Pja2; Kiaa0438; Rnf131; E3 ubiquitin-protein ligase Praja-2; Praja2; EC 2.3.2.27; RING finger protein 131; RING-type E3 ubiquitin transferase Praja-2
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

2-707
氨基酸序列

SQYTEKEPS VMDQESSKAA WPKPAGGYQT ITGRRYGRRH AYVSFKPCMT RHERSLGRAG DDYEVLELDD VPKENTSGSS SLDQVHPALP NEPTVEKSET EISTCGPALN QSTESSPSIA TVCHSEEVRE TLESNTNLHN RTETEHTPAV CNVSSVQNGI MLVHTDSYDP DSKHDENGSL QLGAEAVEGG RHQKGLGRAV FELENGEAEI YADLSPSVPS LNGEISEAFE ELDSAPLEKS STADAELVHQ NGQEFQRSSE DGVVRKRRQD DTDQGRQTEN STEDADCAPG HVEQNTSDRA NHHGSSPEQV VRPKVRKVIS SSQVDQEIGF NRHEAKQRSV QRWREALEVE ECSSDDPIIK CDDYDGDHDC MFLTPTYSRV TQRETERNRV TSENGATASG RQESRDNAFW NACGEYYQLF DKDEDSSECS DGEWSASLPH RFSGTEKDQS SSDDSWETLP GKDENDPELQ SDSSGPEEEN QELSLQEGEQ TSLEEGEIPW LQYNEVNESS SDEGNEPANE FAQPEAFMLD GNNNLEDDSS VSEDLDVDWS LFDGFADGLG VAEAISYVDP QFLTYMALEE RLAQAMETAL AHLESLAVDV EVANPPASKE SIDGLPETLV LEDHTAIGQE QCCPICCSEY IKDDIATELP CHHFFHKPCV SIWLQKSGTC PVCRRHFPPA VIDASAAASS DPDPDASPAN DNAEEAP
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype.
基因功能參考文獻：
1. praja2 regulates KSR1 stability and mitogenic signaling. PMID: 27195677
2. The SIK2-p35-PJA2 complex is essential for glucose homeostasis and provides a link between p35-CDK5 and the AMPK family in excitable cells. PMID: 24561619
亞細胞定位：

Cytoplasm. Cell membrane. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic density.
數據庫鏈接：

KEGG: mmu:224938

STRING: 10090.ENSMUSP00000024888

UniGene: Mm.489681