Recombinant Mouse E3 SUMO-protein ligase NSE2 (Nsmce2)

中文名稱：

小鼠Nsmce2重組蛋白
貨號：

CSB-YP845979MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Nsmce2重組蛋白
貨號：

CSB-EP845979MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Nsmce2重組蛋白
貨號：

CSB-EP845979MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Nsmce2重組蛋白
貨號：

CSB-BP845979MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Nsmce2重組蛋白
貨號：

CSB-MP845979MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Nsmce2
Uniprot No.：

Q91VT1
別名：

Nsmce2; Mms21; E3 SUMO-protein ligase NSE2; EC 2.3.2.-; E3 SUMO-protein transferase NSE2; MMS21 homolog; Non-structural maintenance of chromosomes element 2 homolog; Non-SMC element 2 homolog
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-247
氨基酸序列

MPGRSSTSSG STRYISFSGI ESALSSLKNF QSCISSGMDT VSSVALDLVE TQTEVSSEYS MDKAMVEFAK MDRELSHYVK AVQSTINHVK EERPEKVPDL KLLVEKKFLA LQDKNSDADF KENEKFVQFK QQLRELKKQY GIHADRENDL TEGVDEDMIV TQSQTNFICP ITQLEMKKPV KNKMCGHTYE EEAIVRMIES KHKRKKKACC PKIGCSHTDM RMSDLIPDEA LRRAIESHNK KKKRHSE
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression.
基因功能參考文獻(xiàn)：
1. SUMO- and BLM-independent activities of NSMCE2 limit recombination and facilitate chromosome segregation. PMID: 26443207
亞細(xì)胞定位：

Nucleus. Chromosome, telomere. Nucleus, PML body.
蛋白家族：

NSE2 family
數(shù)據(jù)庫鏈接：

KEGG: mmu:68501

STRING: 10090.ENSMUSP00000078641

UniGene: Mm.27762