Recombinant Mouse Dixin (Dixdc1)

中文名稱：

小鼠Dixdc1重組蛋白
貨號：

CSB-YP770494MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Dixdc1重組蛋白
貨號：

CSB-EP770494MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Dixdc1重組蛋白
貨號：

CSB-EP770494MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Dixdc1重組蛋白
貨號：

CSB-BP770494MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Dixdc1重組蛋白
貨號：

CSB-MP770494MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Dixdc1
Uniprot No.：

Q80Y83
別名：

Dixdc1; Ccd1; Kiaa1735Dixin; Coiled-coil protein DIX1; Coiled-coil-DIX1; DIX domain-containing protein 1
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-711
氨基酸序列

MLACLTRGNL LDVLQEGFNE QQLQAYVAWV NAQLKKRPSV KPVQDLRQDL RDGVILAYLI EIVGQLALDS DASVDERTDF FLLHSPFKAA GEKLTGVQLS PSNQQEMKSN VERVLQFVAS KKIRMHQTSA KDIVEGNLKS IMRLVLALAA HFKPGSSRTV SQGRDSKAPV QSHQPHCATA VAQGAAAALA DVCHDVSRSG RDVFRYRQRN ASVDGEIENP YWSVRALVQQ YEGQQKSPSE SSCSSLTSPS PIHSAKSESI ITQAEEKADF VIIPSEGIEN RTDEPDSPSS RDWRPGSRGT YLEATWEEQL LEQQEHLEKE MEEAKKMISG LQALLLNGSL PEDEQERPVA LCEPGVNPEE QLIIIRSRLD QSVEENQDLK KELLKCKQEA RNLQGIKDAL QQRLTQQDTS VLQLKQELLR ANMDKDELHN QNVDLQRKLE ERNRLLGEYK KELGQKDRLF QQQQAKLEEA LRKLSDASYQ QVDLERELEQ KDVLLAHCMK GETDEVTNYN SHSSQRNGFV LPVAGRGATT VTHRGPQTSD LQLVRDALRS LRNSFSGHDP QHHTIDSLEQ GISSLMERLH VVETQKKQER KVGGRSPRNQ ASSEYRASWP PNSTLPHSQS SPAVSSTCTK VLYFTDRSLT PFMVNIPKRL GEVTLKDFKA AIDREGNHRY HFKALDPEFG TVKEEVFHDD DAIPGWEGKI VAWVEEDHRE N
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.
基因功能參考文獻：
1. DIXDC1 is a regulator of cortical dendrite and synaptic development. PMID: 27829159
2. Abnormal behavior in Dixdc1 mice could elucidate molecular pathophysiology involving Disc1 in major mental illnesses. PMID: 22832659
3. crystals of the Ccd1 DIX domain belonged to space group P2(1)2(1)2(1), with unit-cell parameters a=72.9, b=75.7, c=125.6 A. An X-ray diffraction data set was collected at 3.0 A resolution PMID: 21795788
4. a molecular mechanism for Ccd1-mediated Wnt activation in that Ccd1 converts latent polymeric Dvl to a biologically active oligomer(s). PMID: 21189423
5. DIXDC1 encodes a novel protein with a myosine-tail homologous domain and C-terminal DIX domain PMID: 12792787
6. mouse Ccd1 functions as a positive regulator of the Wnt/beta-catenin pathway. Furthermore, Ccd1 is highly expressed and co-localized with Wnt signaling molecules in the embryonic and adult brain. PMID: 15857680
顯示更多

收起更多
亞細胞定位：

Cell junction, focal adhesion. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm.
蛋白家族：

DIXDC1 family
組織特異性：

Abundantly expressed in brain and testis and to a lower extent in lung, kidney, colon, ovary and urinary bladder. Expressed in brain, liver, testis and spleen (at protein level). Expressed throughout the brain with strong expression in main and accessory
數據庫鏈接：

KEGG: mmu:330938

STRING: 10090.ENSMUSP00000034566

UniGene: Mm.82598