Recombinant Mouse Diphosphoinositol polyphosphate phosphohydrolase 1 (Nudt3)

中文名稱：

小鼠Nudt3重組蛋白
貨號：

CSB-YP881301MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Nudt3重組蛋白
貨號：

CSB-EP881301MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Nudt3重組蛋白
貨號：

CSB-EP881301MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Nudt3重組蛋白
貨號：

CSB-BP881301MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Nudt3重組蛋白
貨號：

CSB-MP881301MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Nudt3
Uniprot No.：

Q9JI46
別名：

Nudt3; Dipp; Dipp1; Diphosphoinositol polyphosphate phosphohydrolase 1; DIPP-1; muDIPP1; EC 3.6.1.52; Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1; EC 3.6.1.-; Nucleoside diphosphate-linked moiety X motif 3; Nudix motif 3
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-168
氨基酸序列

MMKLKSNQTR TYDGDGYKKR AACLCFRSES EEEVLLVSSS RHPDRWIVPG GGMEPEEEPS VAAVREVCEE AGVKGTLGRL VGIFENQERK HRTYVYVLIV TEVLEDWEDS VNIGRKREWF KIEDAIKVLQ CHKPVQASYF ETLRQGYPAN NGTPVVPTTY SSSVSGIR
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5- phosphoribose 1-diphosphate. Acts as a negative regulator of the ERK1/2 pathway. Acts as a decapping enzyme that modulates the stability of a subset of mRNAs implicated in cell motility.
基因功能參考文獻(xiàn)：
1. studies revealed abundant Nudt3 mRNA and protein expression in the mouse brain, including reward- and feeding-related regions of hypothalamus and amygdala, and Nudt3 mRNA expression was up-regulated in hypothalamus and brainstem of food-deprived mice. PMID: 26168034
2. Ectopic expression of murine DIPP1 (muDIPP1)inhibits signal transduction through the ERK1/2 pathway. PMID: 15212765
亞細(xì)胞定位：

Cytoplasm.
蛋白家族：

Nudix hydrolase family, DIPP subfamily
組織特異性：

Present in heart, lung, liver and spleen (at protein level). Widely expressed.
數(shù)據(jù)庫鏈接：

KEGG: mmu:56409

STRING: 10090.ENSMUSP00000025050

UniGene: Mm.144699