Recombinant Mouse Deoxyhypusine hydroxylase (Dohh)

中文名稱(chēng)：

小鼠Dohh重組蛋白
貨號(hào)：

CSB-YP859555MO
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱(chēng)：

小鼠Dohh重組蛋白
貨號(hào)：

CSB-EP859555MO
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱(chēng)：

小鼠Dohh重組蛋白
貨號(hào)：

CSB-EP859555MO-B
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱(chēng)：

小鼠Dohh重組蛋白
貨號(hào)：

CSB-BP859555MO
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱(chēng)：

小鼠Dohh重組蛋白
貨號(hào)：

CSB-MP859555MO
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Dohh
Uniprot No.：

Q99LN9
別名：

DohhDeoxyhypusine hydroxylase; DOHH; EC 1.14.99.29; Deoxyhypusine dioxygenase; Deoxyhypusine monooxygenase
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

full length protein
表達(dá)區(qū)域：

1-302
氨基酸序列

MVTEQEIEAI GKTLVDPKQP LQARFRALFT LRGLGGPDAI SWISRGFEDS SALLKHELAY CLGQMRDARA IPVLADVLQD TSQEPMVRHE AGEALGAIGN PEVLGLLKQY STDPVVEVAE TCQLAVGRLE WLQQHPGEAT CAGPYLSVDP APPAAEQDVG RLREALLDEA RPLFERYRAM FALRNVGGKE AALALAEGLQ CGSALFRHEV GYVLGQLQHE AAVPGLAATL ARTTESPMVR HECAEALGAI ARPACLAALR EHIEDPEQVV RESCEVALDM YEYESSQDFQ YADGLERLRP PP
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
基因功能參考文獻(xiàn)：
1. Deletion of hypusine modification enzymes ( deoxyhypusine synthase and deoxyhypusine hydroxylase )exerts strong phenotypes. eIF-5A2-deleted animals are viable and fertile. PMID: 26037925
2. An evolutionarily conserved role for the DOHH-mediated second step of hypusine synthesis in early embryonic development, is reported. PMID: 24832488
蛋白家族：

Deoxyhypusine hydroxylase family
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:102115

STRING: 10090.ENSMUSP00000072534

UniGene: Mm.294975