Recombinant Mouse Deleted in bladder cancer protein 1 homolog (Dbc1)

中文名稱：

Recombinant Mouse Deleted in bladder cancer protein 1 homolog(Dbc1)
貨號：

CSB-YP842080MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Deleted in bladder cancer protein 1 homolog(Dbc1)
貨號：

CSB-EP842080MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Deleted in bladder cancer protein 1 homolog(Dbc1)
貨號：

CSB-EP842080MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Deleted in bladder cancer protein 1 homolog(Dbc1)
貨號：

CSB-BP842080MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Deleted in bladder cancer protein 1 homolog(Dbc1)
貨號：

CSB-MP842080MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Brinp1
Uniprot No.：

Q920P3
別名：

Brinp1; Brinp; Dbc1; Dbccr1; Fam5aBMP/retinoic acid-inducible neural-specific protein 1; Deleted in bladder cancer protein 1 homolog
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

17-760
氨基酸序列

RISV QPSRQEPAGT DQHVSKEFDW LISDRGPFHH SRSYLSFVER HRQGFTTRYK IYREFARWKV RNTAIERRDL VRHPVPLMPE FQRSIRLLGR RPTTQQFIDT IIKKYGTHLL ISATLGGEEA LTMYMDKSRL DRKSGNATQS VEALHQLASS YFVDRDGTMR RLHEIQISTG AIKVTETRTG PLGCNSYDNL DSVSSVLLQS TESKLHLQGL QIIFPQYLQE KFVQSALSYI MCNGEGEYVC QNSQCRCQCA EEFPQCNCPI TDIQIMEFTL ANMAKAWTEA YKDLENSDEF KSFMKRLPSN HFLTIGSIHQ HWGNDWDLQS RYKLLQSATE AQRQKIQRTA RKLFGLSVRC RHNPNHQLPR ERTIQQWLAR VQSLLYCNEN GFWGTFLESQ RSCVCHGSTT LCQRPIPCII GGNNSCAMCS LANISLCGSC NKGYKLYRGR CEPQNVDSER SEQFISFETD LDFQDLELKY LLQKMDSRLY VHTTFISNEI RLDTFFDPRW RKRMSLTLKS NKNRMDFIHM VIGMSMRICQ MRNSSLDPMF FVYVNPFSGS HSEGWNMPFG EFGYPRWEKI RLQNSQCYNW TLLLGNRWKT FFETVHIYLR SRTRLPTLRN ETGQGPVDLS DPSKRQFYIK ISDVQVFGYS LRFNADLLRS AVQQVNQSYT QGGQFYSSSS VMLLMLDIRD RINRLAPPVA PGKPQLDLFS CMLKHRLKLT NSEIIRVNHA LDLYNTEILK QSDQMTAKLC
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway.
基因功能參考文獻：
1. Brinp1 plays an important role in normal brain development and function by influencing neuronal distribution within the cortex. PMID: 27042284
2. DBC1 loss results in less p53 protein in vitro and in vivo. PMID: 25732823
3. inhibits B cell function by selectively suppressing the transcriptional activity of alternative NF-kappaB pathway upon CD40 stimulation PMID: 25362179
4. Absence of BRINP1 causes deregulation of neurogenesis and impairments of neuronal differentiation in adult hippocampal circuitry. PMID: 24528488
5. Based on these results, the physiological roles of induced BRINP genes in the cell-cycle suppression of terminally differentiated post-mitotic neurons are discussed. PMID: 20025061
6. Data show that neuron-restrictive silencing factor (NRSF) plays a role in the neural-selective expression of BMP/RA-inducible neural-specific protein 1. PMID: 15193422
7. From these results, the physiological roles of the activity-dependent induction of BRINP1-mRNA are discussed. PMID: 17141197
8. The authors show that retinoic acid-inducible gene (RIG)-I-like receptors (RLRs) in cooperation with Toll-like receptor (TLR) 9 is required for expression of type I interferons (IFNs) after infection with herpes simplex virus (HSV). PMID: 19088275
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亞細胞定位：

Cytoplasm.
蛋白家族：

BRINP family
組織特異性：

Expressed in brain. Weakly expressed in embryonic stem (ES) cells and in ES-derived neural stem cells (NSCs).
數據庫鏈接：

KEGG: mmu:56710

STRING: 10090.ENSMUSP00000030036

UniGene: Mm.248788