Recombinant Mouse Dedicator of cytokinesis protein 2 (Dock2), partial

中文名稱：

小鼠Dock2重組蛋白
貨號：

CSB-YP806486MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Dock2重組蛋白
貨號：

CSB-EP806486MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Dock2重組蛋白
貨號：

CSB-EP806486MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Dock2重組蛋白
貨號：

CSB-BP806486MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Dock2重組蛋白
貨號：

CSB-MP806486MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Dock2
Uniprot No.：

Q8C3J5
別名：

Dock2Dedicator of cytokinesis protein 2; Protein Hch
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.
基因功能參考文獻：
1. DOCK2 deficiency protects mice from HFD-induced obesity PMID: 28716822
2. findings showed that DOCK2-driven T cell motility was required to detach from pMHC(low) dendritic cells (DCs)and to find rare presenting peptide-MHCs (pMHCs)(high) DCs. PMID: 28607113
3. DOCK2 is a potential therapeutic target for novel AML treatments, as this protein regulates the survival of leukemia cells with elevated FLT3 activity and sensitizes FLT3/ITD leukemic cells to conventional antileukemic agents. PMID: 27748370
4. Identify DOCK2 as a novel regulator for smooth muscle cell phenotypic modulation and vascular lesion formation after vascular injury. PMID: 25788409
5. DOCK2 is critical for graft facilitating cells to maintain its immunomodulatory function. PMID: 25044556
6. together with DOCK5 contributes to chemotaxis, reactive oxygen species production, and extracellular trap formation PMID: 25339677
7. the IRF5 (-/-) mice with the DOCK2 mutation have higher serum levels of IgG1 and lower levels of IgG2b, IgG2a/c and IgG3 than IRF5 (-/-) mice without the DOCK2 mutation, suggesting that the DOCK2 mutation confers additional Th2-type effects. PMID: 23291967
8. findings reveal a previously unknown, nonredundant role for Elmo1 in controlling Dock2 levels and Dock2-dependent T cell migration in primary lymphocytes. PMID: 24821968
9. DOCK2, an atypical guanine nucleotide exchange factor for Rac, plays a key role in NK cell-mediated cytotoxicity. PMID: 23719299
10. in vivo results presented here suggest DOCK2 contributes to amyloid beta plaque burden via regulation of microglial innate immune function and may represent a novel therapeutic target for Alzheimer's disease PMID: 23318649
11. Results thus indicate that DOCK2 dimerization is functionally important under the physiological condition where only limited amounts of DOCK2 and Rac are localized to the plasma membrane. PMID: 23050005
12. A spontaneous genomic duplication and frameshift mutation in the guanine exchange factor dedicator of cytokinesis 2 (Dock2) that has arisen in at least a subset of circulating Irf5(-/-) mice and inadvertently been bred to homozygosity. PMID: 22431588
13. ASC shapes adaptive immunity independently of inflammasomes by modulating Dock2-dependent Rac activation and actin polymerization in DCs and lymphocytes. PMID: 21892172
14. In plasmacytoid dendritic cells, the DOCK2-Rac signaling pathway acts in parallel with TLR engagement to control IKK-alpha activation for type I IFN induction. PMID: 20231379
15. A review article on the role of DOCK2 in lymphocyte migration. PMID: 12191913
16. plays a role in lymphocyte migration via Rac activation in the cytoskeleton PMID: 12518436
17. DOCK2 regulates T cell responsiveness through remodeling of actin cytoskeleton via Rac activation. PMID: 12871644
18. Deletion of DOCK2, a regulator of the actin cytoskeleton in lymphocytes, suppresses cardiac allograft rejection. PMID: 16230477
19. DOCK2 deficiency causes marked reduction of Valpha14 NKT cells in the thymus, liver, and spleen. PMID: 16585555
20. DOCK2 has a role in regulating chemokine-triggered lateral lymphocyte motility but not transendothelial migration PMID: 16772603
21. Within peripheral lymph nodes, T and B cells require DOCK2 for extensive screening of their respective microenvironments; a central role is shown for DOCK2 during sphingosine-1-phosphate-triggered lymphocyte signaling. PMID: 17325199
22. Dock2 links T cell receptor signals to downregulation of IL-4Ralpha to control the lineage commitment of CD4+ T cells. PMID: 17767160
23. In DOCK2(-/-) plasmacytoid dendritic cells, chemokine-induced Rac activation was severely impaired, resulting in the reduction of motility and the loss of polarity during chemotaxis PMID: 18198348
24. PI3K and Src-ELMO-Dock2 pathways work in parallel to activate Rac2 and modulate chemotaxis in response to a CXCL8 gradient in neutrophils. PMID: 18662984
25. findings show that intracellular DOCK2 dynamics are sequentially regulated by distinct phospholipids to localize Rac activation during neutrophil chemotaxis PMID: 19325080
26. deficiency in DOCK2 significantly impaired CCL21-mediated costimulation in TCR-tg CD4(+) T cells, concomitant with impaired Rac- but not Ras-GTP formation PMID: 19451552
27. Results indicate that the combination of DOCK2 and DOCK180 plays a significant but not essential role in prevascular fetal thymus colonization. PMID: 19728314
28. DOCK2 regulates microglial innate immunity independent of COX2 induction and DOCK2+ microglia are associated with human Alzheimer's disease pathology. PMID: 19729484
29. haematopoietic cell-specific CDM protein family member is indispensable for lymphocyte chemotaxis PMID: 11518968
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亞細胞定位：

Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton.
蛋白家族：

DOCK family
組織特異性：

Specifically expressed in hematopoietic cells.
數據庫鏈接：

KEGG: mmu:94176

STRING: 10090.ENSMUSP00000090884

UniGene: Mm.380679