Recombinant Mouse Cytoskeleton-associated protein 2 (Ckap2)

中文名稱：

Recombinant Mouse Cytoskeleton-associated protein 2(Ckap2)
貨號：

CSB-YP664981MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Cytoskeleton-associated protein 2(Ckap2)
貨號：

CSB-EP664981MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Cytoskeleton-associated protein 2(Ckap2)
貨號：

CSB-EP664981MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Cytoskeleton-associated protein 2(Ckap2)
貨號：

CSB-BP664981MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Cytoskeleton-associated protein 2(Ckap2)
貨號：

CSB-MP664981MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ckap2
Uniprot No.：

Q3V1H1
別名：

Ckap2Cytoskeleton-associated protein 2
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-664
氨基酸序列

MAESRKRFLG RAARNPLPVT RDLQLPPTRR DQPAFREQRK QKLKEYLLIR KTVFPYKQEN QISRDQKMIT SEDRVQEGKK VVKLKTEVAD KENIESTVEK NCIPLKAGEV TSSEIHNSKD NVQAVQLLST RDDLPGQTVT LDPACHHKDN KKMQMTAEKP KQDSNVSKKR VLGYYHGQIV QSKINSFRKL PSVKGESLTT TKKLPTTVSK AMKAQSEPAN TVSVKASTTA AATKFADAKP VSTASKDTLV RPPIRSLHSS SHGAAKQGLS RPLANVTVRK GMLDKESHRS EPVVSVVKAG SSQAPSRSIA SKDAARTDSS NTRLMVKPKD TDQRRYTIAG ASVHRSAQLK DTTAERKAQM TEWRTGKGKG LKRPPHSVVT QAEPKGQSEN PVGSFWTTMA EEDEQRLFTE KVNKTISECL NLINEGCPKE EILATLNDLI HNIPDAKKLV KYWICLVRIE PITSPIENII SIYEKAILAG AQPIEEMRHI IIDILTTKSQ EKVNLGENIE EAHATKEPIQ EVNADANVGS GKPGEENEHH GKVEVYEDDQ DNKIKDPDLT TPDSKTEAGC IIRYNVSSTP RLQSMKKMQH DKNSTLKELK FLTPVRRSRR IQDKTSRLPA MLKDHDPSVS SLEQLSELGG DAFVCRPNAA LCPLFFETDV AEEE
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53-dependent manner.
基因功能參考文獻：
1. The results suggest that the phosphorylation of Cytoskeleton Associated Protein 2 (CKAP2) at T603 and possibly S608 phosphorylation sites by Cyclin Dependent Kinase 1 (CDK1) during mitosis is essential for maintaining the number of centrosomes. PMID: 28706298
2. we found that Lb1-null epicardial cells have a delayed nuclear morphology change in vivo, suggesting that Lb1 facilitates morphological changes associated with migration. These findings suggest that Lb1 contributes to nuclear shape maintenance and migration of epicardial cells PMID: 27798236
3. These data suggest a physiological role of CKAP2 in the formation of spindle bipolarity, which is necessary for maintaining chromosomal stability. PMID: 27055594
4. These findings suggest that CKAP2 is a new MAP with microtubule-stabilizing properties PMID: 15504249
5. Data suggest the existence of a functional positive feedback loop in which Ckap2 activates the G1 tetraploidy checkpoint and prevents aneuploidy. PMID: 16061649
6. The cellular functions of TMAP/CKAP2 might be regulated by timely phosphorylation and dephosphorylation during the course of mitosis. PMID: 18779650
7. Our present findings demonstrate that TMAP/CKAP2 is essential for proper chromosome segregation and for maintaining genomic stability. PMID: 19158495
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亞細胞定位：

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole.
蛋白家族：

CKAP2 family
數據庫鏈接：

KEGG: mmu:80986

STRING: 10090.ENSMUSP00000039518

UniGene: Mm.22448