1. our findings indicate that coronin 1A is a pivotal component that regulates lysosomal fusion and the secretion pathway in osteoclast-lineage cells and may provide a novel therapeutic target for bone diseases. PMID: 28300073
2. these data suggest that coronin 1 is dispensable for mouse NK cell homeostasis and function. PMID: 27717523
3. Results suggest the existence of a hitherto unrecognized coronin 1-dependent decision switch early during life that is responsible for peripheral naive T cell survival and homeostasis. PMID: 28821585
4. Coro1A represents an important novel player in integrin biology, with key functions in polymorphonuclear neutrophils trafficking during innate immunity. PMID: 28615221
5. the phenotype of T cell-specific Coronin 1a deletion resembles the phenotype observed with conventional (whole body) Coronin 1a knock-out mice. In summary, our findings provide formal proof of the predominant T cell-intrinsic role of Coronin 1A. PMID: 27566541
6. Authors report that this mutation induces pleiotropic effects in Coro1A protein, including the exacerbation of Coro1A-dependent actin-binding and -bundling activities. PMID: 26108624
7. Together, these findings both in Jurkat T cells as well as in primary T cells indicate a regulatory role of Coro1A on PKCtheta; recruitment and function downstream of the TCR leading to NF-kappaB transactivation. PMID: 25889880
8. An essential role for 14-3-3 zeta in the regulation of macropinocytosis in macrophages upon cytokine stimulation through modulation of the localization of coronin 1. PMID: 25645340
9. this work suggests that periods before and after NGF-TrkA-induced Coronin-1 expression (and likely other factors) defines two distinct axon growth states PMID: 25740518
10. Absence of coronin 1A is associated with severe combined immunodeficiency in humans, hypomorphic mutations lead to a profound defect in naive T cells, expansion of oligoclonal memory T cells, and susceptibility to Epstein Barr B lymphoproliferation. PMID: 25269405
11. Our results indicate that Abp1 negatively regulates BCR signaling by coupling actin remodeling to B-cell contraction and activation of inhibitory signaling molecules PMID: 24958882
12. Altered T-cell entry and egress in the absence of Coronin 1A attenuates murine acute graft versus host disease. PMID: 24752751
13. These results suggest that coronin 1, while important for naive T cell survival, is dispensable for other leukocyte function under inflammatory conditions in vivo. PMID: 23856257
14. The results of this study establish Coronin-1 as an essential component of a feedback loop that mediates NGF-TrkA endosome stability, recycling and signaling as a critical mechanism governing developmental competition for survival. PMID: 24270184
15. Data suggest that coronin 1 plays a differential role in CD8(+) versus CD4(+) T cell responses and activation. PMID: 23933558
16. Coronin 1 is dispensable for antigen processing and presentation by dendritic cells. PMID: 23099476
17. These results suggest that Coro1a inhibits autophagosome formation in alveolar macrophages, thereby facilitating Mycobacterium tuberculosis survival within the lung. PMID: 22256790
18. Coro1A controls actin association with endocytic organelles, thereby negatively regulating endo-lysosomal delivery, degradation of modified lipoproteins and cholesterol deposition in macrophages. PMID: 22223354
19. GRAIL functions via the ubiquitination and degradation of actin cytoskeleton-associated proteins, in particular Arp2/3-5 and coronin 1A PMID: 22016387
20. required for quiescence and maintenance of adult hematopoietic stem cells PMID: 21885021
21. Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b. PMID: 21844203
22. Coronin 1 is crucial for maintenance of the naive T-cell pool and for development of murine experimental autoimmune encephalomyelitis. PMID: 21289301
23. Coronin-1A activity is not required for mast cell function. PMID: 20643816
24. expressed 10-23 DNAzyme targeting taco gene can reduce TACO expression both at mRNA level (by 78.26%) and at protein level (by 75.30%). PMID: 20059315
25. The leukocyte plasma membrane associates with the actin cytoskeleton through coronin-1. PMID: 15800061
26. coronin-1 is required for an early step in phagosome formation, consistent with a role in actin polymerization PMID: 15829569
27. Analysis of charged and conserved surface residues of coronin-1 delineate possible binding sites for F-actin on the beta propeller PMID: 16407068
28. results show coronin 1 exerted an inhibitory effect on cellular steady-state F-actin formation by an Arp2/3-dependent mechanism in T lymphocytes; it was required for chemokine-mediated migration but dispensable for T cell antigen receptor functions PMID: 16902139
29. These results demonstrate a role for coronin 1 in activating Ca(2+) dependent signaling processes in macrophages and reveal a function for calcineurin in the regulation of phagosome-lysosome fusion upon mycobacterial infection. PMID: 17632055
30. These findings provide further support for the relevance of the LpdC-coronin-1 interaction in phagosome maturation arrest. PMID: 17652161
31. Therefore, these results show that in J774 cells coronin 1 has a specific role in modulating phagosome-lysosome transport upon mycobacterial infection and that it is dispensable for most F-actin-mediated cytoskeletal rearrangements. PMID: 18162581
32. a lupus-suppressing locus is caused by a nonsense mutation of the filamentous actin-inhibiting Coronin-1A gene PMID: 18199416
33. Coronin-1, through activation of Ca2+ release from intracellular stores, is an essential regulator of peripheral lymphocyte survival. PMID: 18345003
34. Findings establish a function for coronin 1A in T cell egress, identify a surface of coronin involved in Arp2/3 regulation. PMID: 18836449
35. Coronin-1A links cytoskeleton plasticity with the functioning of discrete TCR signaling components PMID: 18941544
36. Coronin 1 is dispensable for F-actin-dependent processes and oxidase activity in neutrophils; instead, it is involved in the regulation of calcium dependent signaling reactions. PMID: 19234169

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KEGG: mmu:12721

STRING: 10090.ENSMUSP00000032949

UniGene: Mm.290482