Recombinant Mouse Centrosomal protein of 63 kDa (Cep63)

中文名稱：

Recombinant Mouse Centrosomal protein of 63 kDa(Cep63)
貨號：

CSB-YP659741MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Centrosomal protein of 63 kDa(Cep63)
貨號：

CSB-EP659741MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Centrosomal protein of 63 kDa(Cep63)
貨號：

CSB-EP659741MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Centrosomal protein of 63 kDa(Cep63)
貨號：

CSB-BP659741MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Centrosomal protein of 63 kDa(Cep63)
貨號：

CSB-MP659741MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Cep63
Uniprot No.：

Q3UPP8
別名：

Cep63; D9Mgc48e; Centrosomal protein of 63 kDa; Cep63
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-700
氨基酸序列

MEALLEGIQN RGHSGGFLTS CEAELQELMK QIDIMVAHKK SEWEGQTHAL ETCLDIRDRE LKALRSQLDM KHKEVGILHQ QIEEHEKTKQ EMAMEYKEEL LKLQEELSRL KRSYEKLQKK QLREFRGNTK SFREDRSEIE RLTGKIEEFR QKSLDWEKQR LIYQQQVSSL EAQRKALAEQ SEIIQAQLAN RKQKLESVEL SSQSEIQHLN SKLERAKDTI CANELEIERL NIRVNDLMGT NMTILQDHRQ KEEKLRESEK LLEALQEEQK ELKASLQSQE TFILEAKMQE KLQTTLKAVG TQQSVERPLE DCQKERKYSS PGQGVLDNVL SQLDFSHSSE ELLQAEVTRL EGSLESVSAT CKQLSQELME KYEELKRMEG HNNEYRTEIK KLKEQILQAD QTYSSALEGM KMEISQLTRE LHQRDITIAS AKCSSSDMEK QLKAEMQKAE EKAVEHKEIL SQLESLKLEN HRLSETVMKL ELGLHEAKEI SLADLQENYI EALNKLVSEN QQLQKDLMST KSELEHATNM CKKKDGEIFN PAHSRAAGFK NAELKPIHGQ HRHDGIKTEQ YKTGHHSPRG QTLDSIDPVA RGPSPLSSHI SPGSSTVSLP SNFLFEAHSL PSVLDINDVN FSDSLSDCMN DQEEFVSSGS LPTSPLGSIA TRFLEEEELR SHHILERLDA HIEELKRESE KTVRQFTALV
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and in delay mitotic progression.
基因功能參考文獻：
1. In brain development, Wdr62 and Aspm localize to the proximal end of the mother centriole and interact physically, with Wdr62 required for Aspm localization, and both proteins, as well as microcephaly protein Cep63, required to localize CENPJ/CPAP/Sas-4, a final common target. PMID: 27974163
2. Cep63-deficient mice recapitulate Seckel syndrome pathology, microcephaly and dwarfism. Cep63 loss severely impairs meiotic recombination, leading to profound male infertility. PMID: 26158450
3. both mouse and human Cep63 and Cep152 cooperate to ensure efficient centriole duplication by promoting the accumulation of essential centriole duplication factors upstream of SAS-6 recruitment and procentriole formation. PMID: 23936128
4. Cep63 regulates mother-centriole-dependent centriole duplication. PMID: 24240477
亞細胞定位：

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
蛋白家族：

CEP63 family
數據庫鏈接：

STRING: 10090.ENSMUSP00000091306

UniGene: Mm.38910