Recombinant Mouse Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (Ctdsp1)

中文名稱：

Recombinant Mouse Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1(Ctdsp1)
貨號：

CSB-YP006142MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1(Ctdsp1)
貨號：

CSB-EP006142MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1(Ctdsp1)
貨號：

CSB-EP006142MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1(Ctdsp1)
貨號：

CSB-BP006142MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1(Ctdsp1)
貨號：

CSB-MP006142MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ctdsp1
Uniprot No.：

P58466
別名：

Ctdsp1; Nif3; NliifCarboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; EC 3.1.3.16; Golli-interacting protein; GIP; Nuclear LIM interactor-interacting factor 3; NLI-interacting factor 3; Small C-terminal domain phosphatase 1; SCP1; Small CTD phosphatase 1
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區域：

1-261
氨基酸序列

MDSSAVITQI SKEEARGPLR GKGDQKSAVS QKPRSRGILH SLFCCVCRDD GEPLPAHSGA PLLVEENGAI PKHTPVQYLL PEAKAQDSDK ICVVIDLDET LVHSSFKPVN NADFIIPVEI DGVVHQVYVL KRPHVDEFLQ RMGELFECVL FTASLAKYAD PVADLLDKWG AFRARLFRES CVFHRGNYVK DLSRLGRDLR RVLILDNSPA SYVFHPDNAV PVASWFDNMS DTELHDLLPF FEQLSRVDDV YSVLRQPRPG S
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
基因功能參考文獻：
1. Consistently, the authors observed increased AKT phosphorylation and angiogenesis followed by enhanced tumorigenesis in Ctdsp1 (which encodes SCP1) gene - knockout mice. Importantly, they discovered that the membrane localization of SCP1 is crucial for impeding angiogenesis and tumor growth, and this localization depends on palmitoylation of a conserved cysteine motif within its NH2 terminus. PMID: 28440748
2. Golli-BG21 enhanced SCP1/GIP phosphatase activity, whereas PKCalpha-phosphorylated BG21 inhibited its activity, suggesting a potential role of BG21 as a molecular switch ("quick-brake mechanism") on SCP1/GIP. PMID: 24751520
3. Findings suggest that SCP1 may inhibit the osteoblastic differentiation induced by the BMP-Smad axis via Runx2 by suppressing downstream effector(s). PMID: 21239611
4. Expression and purification of the active variant of recombinant murine Golli-interacting protein (GIP) and its characterization PMID: 18625321
亞細胞定位：

Nucleus.
組織特異性：

Expression is restricted to non-neuronal tissues.
數據庫鏈接：

KEGG: mmu:227292

STRING: 10090.ENSMUSP00000027367

UniGene: Mm.165042