Recombinant Mouse Cancer susceptibility candidate protein 1 (Casc1)

中文名稱：

Recombinant Mouse Cancer susceptibility candidate protein 1(Casc1)
貨號：

CSB-YP764897MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Cancer susceptibility candidate protein 1(Casc1)
貨號：

CSB-EP764897MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Cancer susceptibility candidate protein 1(Casc1)
貨號：

CSB-EP764897MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Cancer susceptibility candidate protein 1(Casc1)
貨號：

CSB-BP764897MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Cancer susceptibility candidate protein 1(Casc1)
貨號：

CSB-MP764897MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Casc1
Uniprot No.：

Q6TDU8
別名：

Casc1; Las1; Protein CASC1; Cancer susceptibility candidate gene 1 protein homolog; Lung adenoma susceptibility protein 1
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-730
氨基酸序列

MAPKSKKAPS KKKMTKAERL RLMQEEEERR LKEEEEARLK FEKEEQERLE IQRIEREKWN LLEKKDLERR SQELEELALL EGCFPEAEKQ KREIRALAQW KHYTECDGSP DPWVAQEMNT FISLWEEEKN QAFEQVMEKS KLVLSLIEKV KLILLETPTY ELDHRTVLQH QGSILRLQEL LSLKINVATE LLLRQASNLA DLDTGNMEKI IKDENVTLYV WANLKKNPRH RSVRFSETQI GFEIPRILAT SNVALRLLHT RYDHITPLFP IAVTEQNQNP VGAEQVNVEE STEKAMTEEK LFTEEKAANE DEQPKAEQER ELNLVQEENK YEAIENTVLQ RTSDSEGEDS QTTQLELEMK LLSEAVLAAQ LCLVENVVEL PEASQAYKVD LCHFSTLGGV YHLDVLELPP QCKPVKGWVL VEILQEGLQR FIYPPDTTEE PDPDVTFPPI EVTLEIHKSV IFFERPRVVR WDNEGKFWRS DGISSVYYNR EDRLLTFSMD TLGPVTLIQD AHVNMPYQSW EMSPCGMNKV LLIVKTVFME LQIYIKENLC MLASVKLRGK GLEFHLKGKW MAPIPFILAL KEAGLNIFPA VYSHFYVVIN NKVPQVELKA YRQMALLSSA FSFGWSKWNM VCNSTRVVIR VREQLSEETE HHTWSLLMFS GDRAQMLKMQ EENDKFSEAL REGTEFHSTL YHMMKDFASP VAMERVRHSN CQFIDSVCYM LLSIRVLSYS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Via its association with the multisubunit axonemal dynein complex, is potentially involved in the regulation of cilia function. May also act as a cell cycle regulator.
基因功能參考文獻：
1. Las1 is part of the complex multigenic Pas1 locus, with a functional role for its intragenic polymorphisms and AA changes in lung tumor susceptibility. It may be a tumor suppressor. PMID: 15064703
2. The differential degradation of Las1-A/J and Las-B6 produced from the 2 corresponding alleles, has important implications for its intracellular function and may eventually explain Las1-A/J in lung tumorigenesis. PMID: 17974961
3. Casc1 knockout mouse tumor bioassays showed that Casc1-deficient mice were susceptible to chemical induction of lung tumors. PMID: 16862160
4. Whole-genome association analyis of lung tumor susceptibility refined the Pas1 locus to a region of less than 0.5 Mb containing two strong candidates, Kras2 and Casc1 (also known as Las1). PMID: 16862160
亞細胞定位：

Cell projection, cilium. Cytoplasm.
蛋白家族：

CASC1 family
組織特異性：

High expressed in lung, kidney, and testis.
數據庫鏈接：

KEGG: mmu:320662

STRING: 10090.ENSMUSP00000062279

UniGene: Mm.207779