Recombinant Mouse Calcium/calmodulin-dependent protein kinase type 1D (Camk1d)

中文名稱：

Recombinant Mouse Calcium/calmodulin-dependent protein kinase type 1D(Camk1d)
貨號：

CSB-YP804869MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Calcium/calmodulin-dependent protein kinase type 1D(Camk1d)
貨號：

CSB-EP804869MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Calcium/calmodulin-dependent protein kinase type 1D(Camk1d)
貨號：

CSB-EP804869MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Calcium/calmodulin-dependent protein kinase type 1D(Camk1d)
貨號：

CSB-BP804869MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Calcium/calmodulin-dependent protein kinase type 1D(Camk1d)
貨號：

CSB-MP804869MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Camk1d
Uniprot No.：

Q8BW96
別名：

Camk1d; Calcium/calmodulin-dependent protein kinase type 1D; EC 2.7.11.17; CaM kinase I delta; CaM-KI delta; CaMKI delta; CaM kinase ID; CaMKI-like protein kinase; CKLiK; mCKLiK
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-385
氨基酸序列

MARENGESSS SWKKQAEDIK KIFEFKETLG TGAFSEVVLA EEKATGKLFA VKCIPKKALK GKESSIENEI AVLRKIKHEN IVALEDIYES PNHLYLVMQL VSGGELFDRI VEKGFYTEKD ASTLIRQVLD AVYYLHRMGI VHRDLKPENL LYYSQDEESK IMISDFGLSK MEGKGDVMST ACGTPGYVAP EVLAQKPYSK AVDCWSIGVI AYILLCGYPP FYDENDSKLF EQILKAEYEF DSPYWDDISD SAKDFIRNLM EKDPNKRYTC EQAARHPWIA GDTALSKNIH ESVSAQIRKN FAKSKWRQAF NATAVVRHMR RLQLGSSLDS SNASVSSNLS LASQKDCLAP STLCSFLSSS SGVAGVGAER RPRPTTVTTG HTGSK
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. Isoform 1 but not isoform 2 activates CREB1.
基因功能參考文獻(xiàn)：
1. Data suggest that, under cell signaling conditions in which Camk1a is significantly dephosphorylated by phosphoprotein phosphatase activity, little Camk1d dephosphorylated is observed. PMID: 25994484
2. CaMKIdelta is involved in nuclear functions through its nuclear translocation in response to stimuli that trigger intracellular Ca2+ influx--Ca2+/calmodulin-dependent protein kinase Idelta. PMID: 16324104
3. CKLiK is up-regulated by the PU.1 transcription factor in murine erythroleukemia cells and is involved in apoptosis of these cells. PMID: 14980499
4. CaMKKalpha was shown to increase during neutrophil differentiation in multiple cell lines, whereas expression of CKLiK increased as multipotent progenitors committed to promyelocytes, but then decreased as cells differentiated into mature neutrophils. PMID: 18400360
亞細(xì)胞定位：

Cytoplasm. Nucleus.
蛋白家族：

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
組織特異性：

Expressed ubiquitously with high levels in brain and low levels in kidney. Isoform 2 is highly expressed in brain compared to other tissues. In hematopoietic cell lines predominant expression was detected in T and EC cells.
數(shù)據(jù)庫鏈接：

KEGG: mmu:227541

STRING: 10090.ENSMUSP00000037028

UniGene: Mm.191949