Recombinant Mouse CD209 antigen-like protein B (Cd209b), partial

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中文名稱：

Recombinant Mouse CD209 antigen-like protein B (Cd209b), partial
貨號：

CSB-EP817227MO
說明書：

MSDS Datasheet
規格：

￥1836
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 95% as determined by SDS-PAGE.
生物活性：

Not Test
基因名：

Cd209b
Uniprot No.：

Q8CJ91
別名：

DC-SIGN-related protein 1;DC-SIGNR1;OtB7;CD antigen CD209
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
來源：

E.coli
分子量：

35.3 kDa
表達區域：

74-325aa
氨基酸序列

QVSKTPNTERQKEQEKILQELTQLTDELTSRIPISQGKNESMQAKITEQLMQLKTELLSRIPIFQGQNESIQEKISEQLMQLKAELLSKISSFPVKDDSKQEKIYQQLVQMKTELFRLCRLCPWDWTFLLGNCYFFSKSQRNWNDAVTACKEVKAQLVIINSDEEQTFLQQTSKAKGPTWMGLSDLKKEATWLWVDGSTLSSRFQKYWNRGEPNNIGEEDCVEFAGDGWNDSKCELKKFWICKKSATPCTEG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.
基因功能參考文獻：
1. Data suggest that SIGNR1(CD209b) expressed in Lewis lung cancer cell-educated macrophages appears to mediate IL-4-induced RAW264.7 macrophage polarization and thus facilitate lung cancer evasion. PMID: 26447454
2. SIGNR1-mediated phagocytosis but not SIGNR1-mediated endocytosis and cell adhesion, suppresses the TLR4-mediated production of specific proinflammatory cytokines via PI3 kinase signaling. PMID: 25226443
3. The subtle carbohydrate preference of SIGNR1 as a phagocytic receptor or as an adhesion molecule is altered depending on the function. PMID: 24434373
4. mediates uptake of mannose-decorated particles leading to cell maturation of peritoneal DC-like cells PMID: 24491912
5. SIGNR1 is involved in the inhibition of DC maturation PMID: 23926325
6. SIGN-R1 in the MZ rapidly accelerates C3 deposition on circulating apoptotic cells by interacting with C1q, thus promoting the systemic clearance of apoptotic cells and maintaining immune tolerance in vivo. PMID: 23238564
7. These results indicate that murine SIGNR1 recognizes C. albicans/yeast through a specificity partly distinct from that of its homologue human DC-SIGN. PMID: 22331432
8. enhances TNF-alpha production by macrophages in cooperation with TLR2 upon microbial recognition PMID: 22207132
9. Toll-like receptor 2-mediated signalling is negatively regulated by SIGNR1-mediated signalling in dendritic cells, possibly through suppressor of cytokine signalling-1-mediated degradation of the MyD88-adaptor-like protein. PMID: 21899704
10. SIGNR1 was shown to enhance the intracellular oxidative burst of macrophages in response to heat killed C. albicans in cooperation with Dectin-1. PMID: 21400494
11. sugar-modified antigens might be used to induce oral tolerance by targeting SIGNR1 and dendritic cells in the gastrointestinal lamina propria (LPDCs). PMID: 20835248
12. isolation of a murine homologue of DC-SIGN that is identical to the previously reported murine homologue mSIGNR1; expressed in marginal zone macrophages PMID: 12351402
13. Dendritic cell-specific ICAM-3-grabbing nonintegrin homolog SIGNR1 has been identified as a major mannose receptor for fungal and other pathogens present on murine resident peritoneal macrophages. PMID: 14707091
14. Recognizes pathogens and contributes to innate immunity. PMID: 16386217
15. data suggest that although SIGNR1 has a similar binding specificity as DC-SIGN, its role is limited during murine M. tuberculosis infection PMID: 17224292
16. Antigens are presented by SIGNR1 expressed by marginal zone macrophages to the developing marginal zone B cell population thereby influencing the repertoire of this B cell population, which is pivotal for the early immune response. PMID: 18343501
17. This study highlights the finding that although there was binding of SIGNR1 to immunogenic factors produced in the S. mansoni life cycle, this recognition does not translate to a functional in vivo role for the PRR during infection. PMID: 18981244
18. These results show that cross-linking of SIGNR1 triggers phosphorylation of SFKs, which leads to activation of the JNK pathway and induction of TNF-alpha production in macrophage-like RAW264.7 cells. PMID: 19520061
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亞細胞定位：

Membrane; Single-pass type II membrane protein.
組織特異性：

Expressed in skin, spleen and lung, probably in a subset of dendritic cells. Detected in spleen extrafollicular paracortical areas including the red pulp and marginal zones, and at lower levels, in the follicular area. Detected in skin suprabasal areas ad
數據庫鏈接：

KEGG: mmu:69165

STRING: 10090.ENSMUSP00000081104

UniGene: Mm.175163